Confounding influence of tamoxifen in mouse models of Cre recombinase-induced gene activity or modulation.

In conclusion, we reveal that TAM increases liver resistance to CCl4-induced toxicity. This finding is of high relevance for studies using the tamoxifen-inducible expression system particularly if this system is used in combination with hepatotoxic compounds such as CCl4.
PMID: 29974145 [PubMed - as supplied by publisher]

Source: Archives of Toxicology - July 4, 2018 Category: Toxicology Authors: Hammad S, Othman A, Meyer C, Telfah A, Lambert J, Dewidar B, Werle J, Nwosu ZC, Mahli A, Dormann C, Gao Y, Gould K, Han M, Yuan X, Gogiashvili M, Hergenröder R, Hellerbrand C, Thomas M, Ebert MP, Amasheh S, Hengstler JG, Dooley S Tags: Arch Toxicol Source Type: research