Association of single nucleotide polymorphisms in resistin gene with rheumatoid arthritis in a Chinese population

Journal of Clinical Laboratory Analysis, EarlyView.
Source: Journal of Clinical Laboratory Analysis - Category: Laboratory Medicine Authors: Source Type: research

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A required postmarketing clinical trial of tofacitinib (Xeljanz, Xeljanz XR) in the treatment of rheumatoid arthritis found an increased risk of pulmonary embolism and death when patients were treated with 10 mg twice daily compared with the currently approved 5 mg twice daily dose.NPs are encouraged to follow tofacitinib's dosing guidelines when treating rheumatoid arthritis.
Source: AJN - Category: Nursing Tags: Drug Watch Source Type: research
This study is active but not recruiting and is registered with ClinicalTrials.gov, number NCT02706951.FindingsPatients were screened between Feb 23, 2016, and May 19, 2017 and 648 were randomly assigned to treatment. 598 (92%) completed week 14. At week 14, an ACR20 response was achieved by 89 (41%) of 216 patients (95% CI 35–48) in the continued methotrexate group, 147 (68%) of 217 patients (62–74) receiving upadacitinib 15 mg, and 153 (71%) of 215 patients (65–77) receiving upadacitinib 30 mg (p
Source: The Lancet - Category: General Medicine Source Type: research
ConclusionPlants of genus Celastrus have been confirmed to show a strong potential for therapeutic and health-maintaining effects, in light of their long traditional use and the phytochemical and pharmacological studies summarized here. Currently, pharmacological studies of this genus mainly focus on Celastrus paniculatus Willd. and Celastrus orbiculatus Thunb. Therefore, more pharmacological investigations should be implemented to support traditional uses of other medicinal plants of the genus Celastrus. Moreover, studies on the toxicity, bioavailability, and pharmacokinetics, in addition to clinical trials, are indispens...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
This study confirms the critical role of PLA2s in arthritis and unveils the distinct contribution of cPLA2α and sPLA2-IIA to the eicosanoid profile in arthritis.
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research
Authors: Aghaloo T, Pi-Anfruns J, Moshaverinia A, Sim D, Grogan T, Hadaya D Abstract Since their development, dental implants have become one of the most common procedures to rehabilitate patients with single missing teeth or fully edentulous jaws. As implants become more mainstream, determining the factors that affect osseointegration is extremely important. Medical risk factors identified to negatively affect osseointegration include diabetes and osteoporosis. However, other systemic conditions and medications that interfere with wound healing have not been as widely investigated. The aim of this systematic revie...
Source: International Journal of Oral and Maxillofacial Implants - Category: ENT & OMF Tags: Int J Oral Maxillofac Implants Source Type: research
Publication date: Available online 23 May 2019Source: Reumatología Clínica (English Edition)Author(s): Juan Alberto Paz-Solarte, Marisa Hernández-Garfella, Amalia Rueda-Cid, Cristina Campos-Fernández, Javier Calvo-Catala
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
(Natural News) Rheumatoid arthritis (RA) is characterized by inflammation, swelling, and pain around the joints and other organs of the body. There is no available cure for RA at present. Patients are only prescribed medications, such as NSAIDs or corticosteroids, to relieve its symptoms and slow down its progression. But for patients who wish to avoid the side...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Ayurvedic treatment comes from traditional Indian medicine. Some people believe that it can help treat inflammatory conditions, such as rheumatoid arthritis. Learn more about Ayurveda here.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Rheumatoid Arthritis Source Type: news
We examined the incidence rate and risk factors of osteoporotic vertebral fracture in RA patients with new-onset CVD (RA-CVD) and evaluated the effects of medications on such fracture risk.MethodsA retrospective study was conducted using a nationwide database from 2000 to 2010: 1267 RA-CVD and 1267 non-CVD patients were enrolled from 30,507 patients with newly diagnosed RA. The main outcome was the development of osteoporotic vertebral fracture. After being adjusted for age, gender, and comorbidities, the Cox proportional hazard model was used to identify independent factors contributing to osteoporotic vertebral fracture....
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
T cell modulation in the clinical background of autoimmune diseases or allogeneic cell and organ transplantations with concurrent preservation of their natural immunological functions (e.g. pathogen defense) is the major obstacle in immunology. An anti human CD4 antibody (MAX.16H5) was applied intravenously in clinical trials for the treatment of autoimmune diseases (e.g. rheumatoid arthritis) and acute late-onset rejection after transplantation of a renal allograft. The response rates were remarkable and no critical allergic problems or side effects were obtained. During the treatment of autoimmune diseases with the murin...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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