Introduction of F446I mutation in the K13 propeller gene leads to increased ring survival rates in Plasmodium falciparum isolates

Mutations in the Plasmodium falciparum k13 gene are associated with artemisinin (ART) resistance. However, it is unclear whether the F446I mutation, the most prevalent allele at the China –Myanmar border and north...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research

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Green Chem., 2019, Accepted Manuscript DOI: 10.1039/C9GC02478F, PaperV ânia Mendes do Prado, Thiago Branquinho Queiroz, Paula M Sa, Rafael Cardoso Seiceira, Nubia Boechat, Fabio Furlan Ferreira Mechanochemistry refers to a chemical reaction induced by mechanical energy involving solids. This method provides several advantages over solution-phase synthesis, such as minimizing the need for large volumes of solvents... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Green Chem. latest articles - Category: Chemistry Authors: Source Type: research
[Cameroon Tribune] Cameroon's imprint in fighting HIV AIDS, TB and malaria is found in its encompassing programme epitomised by the action of the First Lady, Chantal Biya.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
[The Herald] Zimbabwe has paid US$300 000 to the Global Fund to fight Aids, Tuberculosis and Malaria in addition to another US$200 000 which was paid a fortnight ago for its 2017-2019 commitment.
Source: AllAfrica News: HIV-Aids and STDs - Category: Infectious Diseases Source Type: news
[Cameroon Tribune] The event which was yesterday, October 10, 2019 presided over by the French President, Emmanuel Macron ended with donors attaining the 14 billion dollar target.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b01099
Source: Journal of Medicinal Chemistry - Category: Chemistry Authors: Source Type: research
[The Herald] French President Emmanuel Macron reserved rare praise for Zimbabwe for its deepened fight against HIV, tuberculosis (TB) and malaria.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Publication date: January 2020Source: Materials Science and Engineering: C, Volume 106Author(s): Josias Boumbéwendin Gérard Yaméogo, Roseline Mazet, Denis Wouessidjewe, Luc Choisnard, Diane Godin-Ribuot, Jean-Luc Putaux, Rasmané Semdé, Annabelle GèzeAbstractArtemisinin and its derivatives are currently recommended by World Health Organization for the treatment of malaria. Severe malaria requires a parenteral administration of artemisinin-based formulations. However, the effective use of artemisinin is limited by the pharmacokinetic characteristics of the drug (low water solubility,...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
ConclusionsInformation on returning travellers, includes ensuring that the patients receive supervised treatment with the recommended dose of a quality controlled medicine, routine follow-up of all cases, assessment of adequate absorption of the drug, and/or testing the prevalence of molecular markers of drug resistance if validated, can be an important source of an early warning system for emerging resistance.
Source: IDCases - Category: Infectious Diseases Source Type: research
We reported three cases of possible parasite resistance to artemether-lumefantrine therapy. All subjects had complete parasite clearance when treated with other antimalarial drugs. This observation necessitates the urgent need to re-evaluate artemether-lumefantrine medication in Nigeria since it is one of the most commonly used ACT drug.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
We reported three cases of possible parasite resistance to artemether-lumefantrine therapy. All subjects had complete parasite clearance when treated with other antimalarial drugs. This observation necessitates the urgent need to re-evaluate artemether-lumefantrine medication in Nigeria since it is one of the most commonly used ACT drug.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
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