A comparative study of hepatoprotective effect of Inula britannica L aqueous extract and glibenclamide in streptozotocin-induced diabetic mice

In this study, 60 mice were used. Diabetes was experimentally induced by injection of STZ in 50 mice. The levels of blood glucose were evaluated by glucometer strips. Mice with plasma glucose level more than 250  mg/dL were considered diabetic. After 3 days, they were divided randomly into six groups. Groups 1 and 2 served as non-diabetic and untreated diabetic controls, respectively. Group 3 received 30 mg/kg glibenclamide orally. Groups 4, 5, and 6 were given 30, 90, and 270 mg/kg, respectively, ofI. britannica for 20  days orally. At 20th day, the mice were dissected; blood and liver samples collected for hematological, biochemical, and histological parameter analysis. Hematologically,I. britannica and glibenclamide could reduce significantly (p ≤ 0.05) the raised levels of WBC, platelet, and increased RBC number as compared to the untreated group. Biochemically,I. britannica at all dose (especially IB270) and glibenclamide could significantly (p  ≤ 0.05) reduce the raised levels of glucose, ALP, AST, ALT, cholesterol, LDL, and increased HDL, SOD, and CAT levels as compared to the untreated group. Histologically, different doses ofI. britannica (especially IB270) similar to glibenclamide could significantly (p  ≤ 0.05) decreased the volume of the liver structures as compared to the untreated group. It concluded thatI. britannica could ameliorate hyperglycemia and improved hepatic changes following diabetes in STZ-induced diabetic mice. So, according to ...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research