Deciphering the complexities of atopic dermatitis: Shifting paradigms in treatment approaches

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. It often precedes the development of food allergy and asthma. Recent insights into AD reveal abnormalities in terminal differentiation of the epidermal epithelium leading to a defective stratum corneum, which allows enhanced allergen penetration and systemic IgE sensitization. Atopic skin is also predisposed to colonization or infection by pathogenic microbes, most notably Staphylococcus aureus and herpes simplex virus.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Reviews and feature article Source Type: research