Magnesium Balance in Chronic and End-Stage Kidney Disease

This article explores the effects of CKD and end-stage kidney disease on magnesium balance. In CKD, there is decreased glomerular filtration of magnesium. Decreased tubular reabsorption can compensate to a degree, but once CKD stage 4 is reached there is a tendency toward hypermagnesemia. In dialysis, magnesium balance is dependent on the constituents of the dialysate that the blood is exposed to. The concentration of dialysate magnesium is just one of the factors that need to be considered. During transplantation, there are particular effects of immunosuppressants that can affect the magnesium balance and need to be considered by the clinician.
Source: Advances in Chronic Kidney Disease - Category: Urology & Nephrology Source Type: research

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Chronic kidney disease (CKD) currently affects approximately 15% of the US population or 30 million US adults,1 but incidence is projected to increase over the next 2 decades due to the ongoing obesity epidemic and the aging of the US population.2 Almost half of all US adults aged 65 years and older are predicted to develop CKD during their lifetime.2 The economic impact of CKD is substantial. Despite the fact that end-stage renal disease (ESRD), the most severe stage of CKD requiring kidney transplant or dialysis, is experienced only 650,000 US persons, the Medicare costs alone exceed $33 billion annually.
Source: Journal of the American Dietetic Association - Category: Nutrition Authors: Tags: From the Academy Source Type: research
This article reviews the clinical case for a special emphasis on this transition period, reviews published literature regarding prior transitional care programs, and proposes a novel iteration of the first 30 days of dialysis care: the transitional care unit (TCU). The goal of a TCU is to improve awareness of all aspects of renal replacement therapy, including modalities, access, transplantation options, and nutritional and psychosocial aspects of the disease. This enables patients to make truly informed decisions regarding their care. The TCU model is open to all patients, including incident patients with end-stage renal ...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
AbstractPurpose of ReviewThe choice of optimum transplant in a patient with type 1 diabetes mellitus (T1DM) and chronic kidney disease stage V (CKD V) is not clear. The purpose of this review was to investigate this in more detail —in particular the choice between a simultaneous pancreas-kidney transplantation (SPKT) and living donor kidney transplantation (LDKT), including recent evidence, to aid clinicians and their patients in making an informed choice in their care.Recent FindingsAnalyses of large databases have recently shown SPKT to have better survival rates than a LDKT in the long-term, despite an early incre...
Source: Current Diabetes Reports - Category: Endocrinology Source Type: research
ConclusionsPulmonary hypertension is associated with a substantially increased risk for death and cardiovascular events in patients with CKD and ESRD. Risk is higher in patients with ESRD receiving dialysis compared with patients with CKD stages 1 to 5. Understanding the effect of interventions to lower pulmonary artery pressure on the survival of these patents awaits their evaluation in randomized controlled trials.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
This article explores the effects of CKD and end-stage kidney disease on magnesium balance. In CKD, there is decreased glomerular filtration of magnesium. Decreased tubular reabsorption can compensate to a degree, but once CKD stage 4 is reached there is a tendency toward hypermagnesemia. In dialysis, magnesium balance is dependent on the constituents of the dialysate that the blood is exposed to. The concentration of dialysate magnesium is just one of the factors that need to be considered. During transplantation, there are particular effects of immunosuppressants that can affect the magnesium balance and need to be consi...
Source: Advances in Chronic Kidney Disease - Category: Urology & Nephrology Source Type: research
ConclusionDialysis of children before KTx was a particularly larger burden for caregivers. The child ’s comorbidities and social adaptation problems might be focused after KTx, we need to evaluate for more long-term QOL of caregivers.
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
This article explores the effects of CKD and end-stage kidney disease on magnesium balance. In CKD, there is decreased glomerular filtration of magnesium. Decreased tubular reabsorption can compensate to a degree, but once CKD stage 4 is reached there is a tendency toward hypermagnesemia. In dialysis, magnesium balance is dependent on the constituents of the dialysate that the blood is exposed to. The concentration of dialysate magnesium is just one of the factors that need to be considered. During transplantation, there are particular effects of immunosuppressants that can affect the magnesium balance and need to be consi...
Source: Advances in Chronic Kidney Disease - Category: Urology & Nephrology Source Type: research
ConclusionsPulmonary hypertension is associated with a substantially increased risk for death and cardiovascular events in patients with CKD and ESRD. Risk is higher in patients with ESRD receiving dialysis compared with patients with CKD stages 1 to 5. Understanding the effect of interventions to lower pulmonary artery pressure on the survival of these patents awaits their evaluation in randomized controlled trials.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
Chronic kidney diseases affect 10 percent of men and nearly 12 percent of women around the world. Up to 10.5 million people need dialysis or a kidney transplant, but many don't get these treatments due to cost or lack of resources, the International Society of Nephrology says.
Source: WebMD Health - Category: Consumer Health News Source Type: news
CONCLUSIONS: Successful kidney transplantation leads to the normalization of serum concentrations of hormones linked to fertility disorders in women with chronic kidney disease. . PMID: 29952423 [PubMed - in process]
Source: Endokrynologia Polska - Category: Endocrinology Authors: Tags: Endokrynol Pol Source Type: research
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