Magnesium Balance in Chronic and End-Stage Kidney Disease

This article explores the effects of CKD and end-stage kidney disease on magnesium balance. In CKD, there is decreased glomerular filtration of magnesium. Decreased tubular reabsorption can compensate to a degree, but once CKD stage 4 is reached there is a tendency toward hypermagnesemia. In dialysis, magnesium balance is dependent on the constituents of the dialysate that the blood is exposed to. The concentration of dialysate magnesium is just one of the factors that need to be considered. During transplantation, there are particular effects of immunosuppressants that can affect the magnesium balance and need to be considered by the clinician.
Source: Advances in Chronic Kidney Disease - Category: Urology & Nephrology Source Type: research

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Publication date: Available online 15 February 2019Source: Best Practice &Research Clinical Obstetrics &GynaecologyAuthor(s): Emily Haesler, Nabil Melhem, Manish D. SinhaAbstractRenal disease in women of childbearing age is estimated to be around 3%, consequently renal disease is not an uncommon co-morbidity in pregnancy. There has been considerable evidence published over the last 20 years to suggest that renal disease in pregnancy is associated with higher maternal, fetal and offspring morbidity. Studies published are largely heterogeneous, include unmatched cohort studies and focus on early neonatal outcomes suc...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
Forty million people in Western Europe have chronic kidney disease (CKD).1 The number of patients receiving renal replacement therapy (RRT) increased by 23% from 2006 to 2015.2,3 Males predominate on dialysis. The mean age of patients receiving dialysis is 61.3 years, and 19% are over 80 years.3 Hemodialysis and transplantation predominate, costing around €40,000 to €80,000 and €10,000 to €20,000 per patient per year, respectively.1 Overall, 2% of health expenditure is consumed by RRT for 0.1% of the population.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Policy Forum Source Type: research
Vadadustat is a potential new treatment for anemia in chronic kidney disease -- but what do we know about its impacts in patients receiving hemodialysis?Nephrology Dialysis Transplantation
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news
AbstractChronic kidney disease (CKD) is an increasingly prevalent condition globally and is strongly associated with incident cardiovascular disease (CVD). Hypertension is both a cause and effect of CKD and affects the vast majority of CKD patients. Control of hypertension is important in those with CKD as it leads to slowing of disease progression as well as reduced CVD risk. Existing guidelines do not offer a consensus on optimal blood pressure (BP) targets. Therefore, an understanding of the evidence used to create these guidelines is vital when considering how best to manage individual patients. Non-pharmacological int...
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
Conclusions: There are important implications of the screening. First, detection of the undiagnosed patients leads to starting appropriate therapies for these patients. Second, the transmission of the disease to future generations may be prevented by prenatal screening after appropriate genetic counseling. In conclusion, we suggest screening of kidney Tx candidates for FD, regardless of etiologies of chronic kidney disease.Nephron
Source: Nephron - Category: Urology & Nephrology Source Type: research
AbstractBackgroundWomen with chronic kidney disease commonly have menstrual irregularities and fertility abnormalities. Antim üllerian hormone (AMH) and antral follicle count (AFC) are well-recognized indicators of ovarian reserve.AimsTo assess AMH level and total AFC in women who are on hemodialysis and after successful kidney transplantation (KTx).MethodsSixty women with end-stage kidney disease (ESKD) on regular hemodialysis were included in this study with 20 patients of them were going to have renal transplant. Fifty age-matched healthy females were enrolled as control. Serum AMH level was measured in all partici...
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
A new review investigates the potential link between bone, inflammation, and the bone marrow niche in chronic kidney disease.Nephrology Dialysis Transplantation
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news
AbstractBackgroundObesity is a risk factor for chronic kidney disease (CKD) and a relative contraindication for renal transplantation. Bariatric surgery (BS) is an option to address this issue but we hypothesize that severe CKD is associated with a loss of efficacy of BS which could justify recommending it at an earlier stage of the CKD.MethodsA retrospective study (n = 101 patients) to test primarily for differences in weight loss at 6 and 12 months according to estimated glomerular filtration rate categories (eGFR 
Source: Obesity Surgery - Category: Surgery Source Type: research
As chronic kidney disease progresses to end-stage renal disease (ESRD), important discussions regarding when and if to initiate dialysis occur. ESRD affects more than 660,000 Americans, less than 10,000 (1.5%) of those are pediatric patients whose time on dialysis is typically meant as a bridge to transplant. In rare circumstances, comorbidities, such as multiorgan failure, progression of other life-threating medical conditions, congenital anomalies, and size restrictions limit pediatric candidates ’ access to transplant.
Source: Journal of Pain and Symptom Management - Category: Palliative Care Authors: Source Type: research
che N Abstract Hemophilia A is an X-linked genetic hemorrhagic disorder characterized by a factor VIII deficiency. The availability of secured substitution products has led to a dramatic improvement of life expectancy in hemophiliac patients. Nowadays, adult hemophiliac patients may develop Chronic Kidney Disease (CKD) resulting from age-related comorbidities (hypertension, obesity, diabetes). In addition, the high prevalence of viral infections in this population exposes patients to an increased risk of CKD. The risk of hemorrhage in hemophiliac patients is a challenge for their clinical management, both for...
Source: Nephrologie and Therapeutique - Category: Urology & Nephrology Authors: Tags: Nephrol Ther Source Type: research
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