The host response as a tool for infectious disease diagnosis and management.

The host response as a tool for infectious disease diagnosis and management. Expert Rev Mol Diagn. 2018 Jun 25;: Authors: Lydon EC, Ko ER, Tsalik EL Abstract INTRODUCTION: A century of advances in infectious disease diagnosis and treatment changed the face of medicine. However, challenges continue to develop including multi-drug resistance, globalization that increases pandemic risks, and high mortality from severe infections. These challenges can be mitigated through improved diagnostics, and over the past decade, there has been a particular focus on the host response. Since this article was originally published in 2015, there have been significant developments in the field of host response diagnostics, warranting this updated review. Areas Covered: This review begins by discussing developments in single biomarkers and pauci-analyte biomarker panels. It then delves into 'omics, an area where there has been truly exciting progress. Specifically, progress has been made in sepsis diagnosis and prognosis; differentiating viral, bacterial, and fungal pathogen classes; pre-symptomatic diagnosis; and understanding disease-specific diagnostic challenges in tuberculosis, Lyme disease, and Ebola. Expert Commentary: As 'omics have become faster, more precise, and less expensive, the door has been opened for academic, industry, and government efforts to develop host-based infectious disease classifiers. While there are still obstacles to overcome, the chasm separati...
Source: Expert Review of Molecular Diagnostics - Category: Laboratory Medicine Tags: Expert Rev Mol Diagn Source Type: research

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ConclusionBlood sampling at 2 and 4  h, combined with model-based prediction, can be used instead of the currently used linear regression strategy, shortening the sampling by 2 h and one sampling point without performance loss while simultaneously offering flexibility in sampling times.
Source: Clinical Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research
Authors: Poeta P, Silva V, Guedes A, Eduardo Pereira J, Cláudia Coelho A, Igrejas G Abstract Tuberculosis is an infectious bacterial disease with a high mortality rate worldwide constituting a serious public health problem. The diagnostic methods commonly used by health professionals are slow and expensive and the results may take about sixty days which will cause a delay in administrating the most proper treatment to the patient, as well as increase health care costs and infection transmission possibility. Patients infected simultaneously with human immunodeficiency virus and Mycobacterium tuberculosis are ...
Source: Experimental Lung Research - Category: Respiratory Medicine Tags: Exp Lung Res Source Type: research
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C8OB03088J, PaperRodrigo Octavio M A de Souza, Renata Aguiar, Raquel A C Le ão, Leandro S M Miranda, C. Oliver Kappe, David Cantillo, Alejandro Mata Continuous-flow production of chiral intermediates plays an important role in the development of building blocks for Active Pharmaceutical Ingredients (APIs), being α-amino acids and their derivatives widely applied as building... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
Authors: Savaş N, Barutcu G, Yeniçeri A Abstract OBJECTIVE: The aim of the study was to evaluate results of purified protein derivates (PPD) test applied at the Tuberculosis Dispensary between 2012-2015 in Hatay, Turkey, where a large number of Syrian refugees have migrated since the Syrian civil war began in 2011. METHODS: PPD test records from the Electronic Tuberculosis Management System at the Tuberculosis Dispensary from 2012-2015 were analyzed based on nationality, age groups, BCG scar availability, and PPD reaction. The annual risk of tuberculosis infection (ARTI) was calculated based on years fo...
Source: Central European Journal of Public Health - Category: International Medicine & Public Health Tags: Cent Eur J Public Health Source Type: research
(Massachusetts General Hospital) Screening all hospitalized patients with HIV for tuberculosis using urine tests would improve life expectancy and be cost-effective in Malawi and South Africa, reports an international team of investigators led by Massachusetts General Hospital physicians.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
British scientists are developing gene-edited chickens designed to be totally resistant to flu in a new approach to trying to stop the next deadly human pandemic.
Source: CBC | Health - Category: Consumer Health News Tags: News/Health Source Type: news
Where are the Ebola diagnostics from last time?, Published online: 22 January 2019; doi:10.1038/d41586-019-00212-yAnalysis reveals commercial tests for Ebola are too hard to come by in the current outbreak — sustain investment, urge Lieselotte Cnops, Kevin K. Ariën and colleagues.
Source: Nature AOP - Category: Research Authors: Source Type: research
lazevic Norovirus (NoV) genotype GII.4 is responsible for the majority of NoV infections causing pandemics every few years. A NoV virus-like particle (VLP)-based vaccine should optimally cover the high antigenic variation within the GII.4 genotype. We compared the immune responses generated by VLPs of the ancestral GII.4 1999 strain (GII.4 1995/96 US variant) and the most recent GII.4 Sydney 2012 pandemic strains in mice. No significant differences were observed in the type-specific responses but GII.4 1999 VLPs were more potent in inducing high-avidity antibodies with better cross-reactivity. GII.4 1999 immune sera bl...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Medanta - The Medicity, a multi-super specialty corporate hospital in Gurugram, Haryana launched a “TB-Free Haryana” Campaign; mobile van equipped with a digital CXR machine to screen patients with presumptive...
Source: BMC Public Health - Category: Consumer Health News Authors: Tags: Research article Source Type: research
by David J. Haw, Derek A. T. Cummings, Justin Lessler, Henrik Salje, Jonathan M. Read, Steven Riley Infectious disease transmission in animals is an inherently spatial process in which a host’s home location and their social mixing patterns are important, with the mixing of infectious individuals often different to that of susceptible individuals. Although incidence data for humans have tradit ionally been aggregated into low-resolution data sets, modern representative surveillance systems such as electronic hospital records generate high volume case data with precise home locations. Here, we use a gridded spatial t...
Source: PLoS Computational Biology - Category: Biology Authors: Source Type: research
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