The host response as a tool for infectious disease diagnosis and management.

The host response as a tool for infectious disease diagnosis and management. Expert Rev Mol Diagn. 2018 Jun 25;: Authors: Lydon EC, Ko ER, Tsalik EL Abstract INTRODUCTION: A century of advances in infectious disease diagnosis and treatment changed the face of medicine. However, challenges continue to develop including multi-drug resistance, globalization that increases pandemic risks, and high mortality from severe infections. These challenges can be mitigated through improved diagnostics, and over the past decade, there has been a particular focus on the host response. Since this article was originally published in 2015, there have been significant developments in the field of host response diagnostics, warranting this updated review. Areas Covered: This review begins by discussing developments in single biomarkers and pauci-analyte biomarker panels. It then delves into 'omics, an area where there has been truly exciting progress. Specifically, progress has been made in sepsis diagnosis and prognosis; differentiating viral, bacterial, and fungal pathogen classes; pre-symptomatic diagnosis; and understanding disease-specific diagnostic challenges in tuberculosis, Lyme disease, and Ebola. Expert Commentary: As 'omics have become faster, more precise, and less expensive, the door has been opened for academic, industry, and government efforts to develop host-based infectious disease classifiers. While there are still obstacles to overcome, the chasm separati...
Source: Expert Review of Molecular Diagnostics - Category: Laboratory Medicine Tags: Expert Rev Mol Diagn Source Type: research

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In this study, we investigated the use of the QFT system with measurement of IFN-γ and IP-10 in parallel to identify M. bovis-infected African buffaloes. The test results of either biomarker in a cohort of M. bovis-unexposed buffaloes (n = 70) led to calculation of 100% test specificity. Furthermore, in cohorts of M. bovis culture-positive (n = 51) and M. bovis-suspect (n = 22) buffaloes, the IP-10 test results were positive in a greater number of animals than the number based on the IFN-γ test results. Most notably, when the biomarkers were measured in parallel, the te...
Source: Preventive Veterinary Medicine - Category: Veterinary Research Source Type: research
Publication date: Available online 23 May 2019Source: BiologicalsAuthor(s): Kathryn Edwards, Germaine Hanquet, Steve Black, Emmanuel Mignot, Christopher Jankosky, Tom Shimabukuro, Elizabeth Miller, Hanna Nohynek, Pieter NeelsAbstractA group of scientific and public health experts and key stakeholders convened to discuss the state of knowledge on the relationship between adjuvanted monovalent inactivated 2009 influenza A H1N1 vaccines used during the 2009 influenza pandemic and narcolepsy. There was consensus that an increased risk of narcolepsy was consistently observed after Pandemrix (AS03-adjuvanted) vaccine, but simila...
Source: Biologicals - Category: Biology Source Type: research
[Citizen] Dar es Salaam -The East African Community (EAC) warned ebola remained a major threat to the region and asked countries to prepare to stop the spread of the deadly hemorrhagic fever that has so far claimed over 1, 000 lives in DR Congo.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Conclusion Although the HRCT findings for pulmonary tuberculosis associated with IP are atypical, appropriate tuberculosis treatments can lead to favorable outcomes. PMID: 31118378 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
[The New Humanitarian] Goma/Democratic Republic of Congo -The second-largest Ebola outbreak ever continues to spread, and health officials now say it's likely to reach the populous city of Goma. Once there, the risk of it spreading beyond the Democratic Republic of Congo to Rwanda, South Sudan, or Uganda increases.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
[Thomson Reuters Foundation] As the Ebola outbreak in DRC shows no signs of relenting, and the security situation remains unpredictable, the UN announced on Thursday that it is strengthening its response to the deadly virus.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Authors: Cachay R, Schwalb A, Mora R, Cáceres T, Gotuzzo E PMID: 31116332 [PubMed - in process]
Source: Revista Peruana de Medicina de Experimental y Salud Publica - Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research
We report the case of a six-monthold male infant with a history of having received the BCG vaccine at birth, and presenting repeated infectious, soft violet nodules in the trunk and extremities with the presence of acid-alcohol-resistant bacilli (BAAR) in histopathology and skin culture; the molecular study reported the presence of Mycobacterium bovis BCG. In the tomography, interstitial opacities were observed in the lungs and in the gastric lavage BAAR was identified. The genetic study of the patient and the mother revealed the presence of a mutation in the IL2RG gene confirming the diagnosis of severe combined immunodef...
Source: Revista Peruana de Medicina de Experimental y Salud Publica - Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research
Research from Queen Mary University in London found doctors were seeing Spanish flu for years before it exploded into a pandemic which infected a third of the world's population.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
ConclusionsDue to the high risk of developing tuberculosis, the possibility of prophylactic administration of anti-tuberculosis agents to patients with head and neck carcinoma should be investigated, although prophylactic administration is not a cost-effective option for all patients with head and neck carcinoma. However, if tuberculosis onset occurs, it leads to various problems; it has a major impact on not only patients with cancer but also various people in the social environment. In the future, it is essential to consider prophylactic administration in patients requiring long-term maintenance drug therapy, especially ...
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
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