The AGES-Reykjavik Study suggests that change in kidney measures is associated with subclinical brain pathology in older community-dwelling persons

Decreased glomerular filtration rate (GFR) and albuminuria may be accompanied by brain pathology. Here we investigated whether changes in these kidney measures are linked to development of new MRI-detected infarcts and microbleeds, and progression of white matter hyperintensity volume. The study included 2671 participants from the population-based AGES-Reykjavik Study (mean age 75, 58.7% women). GFR was estimated from serum creatinine, and albuminuria was assessed by urinary albumin-to-creatinine ratio.

Source: Kidney International - June 27, 2018 Category: Urology & Nephrology Authors: Sanaz Sedaghat, Jie Ding, Gudny Eiriksdottir, Mark A. van Buchem, Sigurdur Sigurdsson, M. Arfan Ikram, Osorio Meirelles, Vilmundur Gudnason, Andrew S. Levey, Lenore J. Launer Tags: Clinical Investigation Source Type: research