Metformin is associated with a lower risk of active tuberculosis in patients with type 2 diabetes

Respirology, EarlyView.
Source: Respirology - Category: Respiratory Medicine Authors: Source Type: research

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Adequate nutrition from which amino acids are part gives us protection against infectious or metabolic diseases. In particular, glycine has immunomodulatory properties and is a secretagogue of insulin. However, its absorption rate or plasma levels are impaired in bacterial infection or high glucose levels. The aim of this study was to evaluate the association between glycine and insulin plasma levels in patients with pulmonary tuberculosis (PTB) and type 2 diabetes mellitus (DM2).
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Short Communication Source Type: research
Publication date: Available online 14 January 2020Source: Inorganica Chimica ActaAuthor(s): Dieter RehderAbstractLight is thrown on the impact of vanadium compounds in medicinal issues, including simple inorganic vanadates, such as vanadates stabilized (and thus possibly modified) by organic counter-ions. The main fields of potential medications (and limits thereof) based on vanadium so far do not (yet) enjoy official pharmacological application. However, several sectors of the potentially successful treatment of pathological symptoms with vanadium (coordination) compounds have been thoroughly and mostly successfully inves...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
Authors: Torres M, Herrera MT, Fabián-San-Miguel G, Gonzalez Y Abstract Diabetes mellitus, a metabolic disease characterized by hyperglycemia and poor glucose control, is a risk factor for Mycobacterium tuberculosis (M. tuberculosis) infection and the development of active tuberculosis. To evaluate whether M. tuberculosis infection susceptibility is associated with an intrinsic factor in monocytes from type 2 diabetes (T2D) patients or it is associated with hyperglycemia per se, we analyzed TLR-2 and TLR-4 expression by flow cytometry and the cytokines IL-1β, IL-6, IL-8, IL-10, and TNF-α by cytome...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Conclusions:Screening for TB among diabetics in routine governmental healthcare services was successfully implemented. Screening DM patients in countries with a high prevalence of DM will reveal a significant number of active TB cases, which will in turn improve the case detection rate of TB.
Source: Journal of Preventive Medicine and Hygiene - Category: International Medicine & Public Health Source Type: research
Treatment of patients with tuberculosis with XDR combined with diabetes mellitus (DM) is difficult due to the more frequent development of neurotoxic unwanted adverse reactions (UAR) against the background of diabetic neuropathy.Objective: to assess the tolerability of the V chemotherapy regimen, including bedaquiline (Sirturo®) and linezolid (Zivox®) in patients with pulmonary tuberculosis with XDR combined with diabetes when prescribing thioctic acid (Thioctacid®) for the prevention and relief of UAR.126 TB patients with XDR and type 2 DM were observed: main group 1G (n = 66 people) and comparison group 2G (n...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research
Publication date: Available online 11 November 2019Source: Prostaglandins &Other Lipid MediatorsAuthor(s): Rupak Shivakoti, Jesmond Dalli, Dileep Kadam, Sanjay Gaikwad, Madhusudan Barthwal, Romain A. Colas, Francesca Mazzacuva, Rahul Lokhande, Sujata Dharmshale, Renu Bharadwaj, Anju Kagal, Neeta Pradhan, Sona Deshmukh, Sachin Atre, Tushar Sahasrabudhe, Arjun Kakrani, Vandana Kulkarni, Swapnil Raskar, Nishi Suryavanshi, Sandy ChonABSTRACTIndividuals with concurrent tuberculosis (TB) and Type 2 diabetes (DM) have a higher risk of adverse outcomes. To better understand potential immunological differences, we utilized a co...
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research
In this study, we hypothesized that moderately and chronically reducing ACh could attenuate the deleterious effects of aging on NMJs and skeletal muscles. To test this hypothesis, we analyzed NMJs and muscle fibers from heterozygous transgenic mice with reduced expression of the vesicular ACh transporter (VAChT), VKDHet mice, which present with approximately 30% less synaptic ACh compared to control mice. Because ACh is constitutively decreased in VKDHet, we first analyzed developing NMJs and muscle fibers. We found no obvious morphological or molecular differences between NMJs and muscle fibers of VKDHet and contro...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 2 November 2019Source: Microbes and InfectionAuthor(s): Adrian Rodriguez-Carlos, Claudia Valdez-Miramontes, Paulina Marin-Luevano, Irma González-Curiel, Jose A. Enciso-Moreno, Bruno Rivas-SantiagoAbstractDiabetes has been associated with an increased risk of developing tuberculosis. The reasons related to the increased susceptibility to develop TB in type 2 diabetes mellitus (T2DM) individuals, has not been completely elucidated. However, this susceptibility has been attributed to several factors including failures and misfunctioning of the immune system. In the present study, we a...
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research
by Yuanwei Xu, Irving Cancino-Mu ñoz, Manuela Torres-Puente, Luis M. Villamayor, Rafael Borrás, María Borrás-Máñez, Montserrat Bosque, Juan J. Camarena, Ester Colomer-Roig, Javier Colomina, Isabel Escribano, Oscar Esparcia-Rodríguez, Ana Gil-Brusola, Concepción Gimeno, Adelina Gimeno-Gascón, Bárbara Gomila-Sard, Damiana G onzález-Granda, Nieves Gonzalo-Jiménez, María Remedio Guna-Serrano, José Luis López-Hontangas, Coral Martín-González, Rosario Moreno-Muñoz, David Navarro, María Navarro, Nie...
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
James Peyer, formerly of Apollo Ventures and now at the larger Kronos BioVentures, has a range of interesting views on the new and growing longevity biotechnology industry. Apollo Ventures was one of the earlier longevity-focused funds to emerge from the comparatively small community of scientists, patient advocates, and investors enthusiastic to accelerate progress towards the treatment of aging as a medical condition. The presentation here was given earlier this year at the Ending Age-Related Diseases conference organized by the Life Extension Advocacy Foundation. In the matter of creating new medical therapies, t...
Source: Fight Aging! - Category: Research Authors: Tags: Healthy Life Extension Community Source Type: blogs
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