Effect of Prunus yedoensis Matsumura extract on the gene expression in HaCaT cells

ConclusionThe present study demonstrated that PYE at 313 μg/mL, a concentration which is not cytotoxic but generates intracellular ROS, affected gene regulation in HaCaT human keratinocytes through multiple toxicity mechanisms and could therefore disturb skin homeostasis or lead to skin aging. We propose that for the safe use of PYE in herbal cosmetic or medicines, further evaluations of the toxicity and safety in the skin must be performed.

http://link.springer.com/10.1007/s13273-018-0037-x

Source: Molecular and Cellular Toxicology - June 23, 2018 Category: Cytology Source Type: research