Electrochemical remediation of amoxicillin: Detoxification and reduction of antimicrobial activity.

Electrochemical remediation of amoxicillin: Detoxification and reduction of antimicrobial activity. Chem Biol Interact. 2018 Jun 16;: Authors: Brito LB, Garcia LF, Caetano MP, Lobón GS, Teles de Oliveira M, de Oliveira R, Sapateiro Torres IM, Yepez A, Vaz BG, Luque R, Grisolia CK, Valadares MC, de Souza Gil E, Rodrigues de Oliveira GA Abstract Amoxicillin (AMX) is one of the most commonly prescribed antibiotics around the world to treat and prevent several diseases in both human and veterinary medicine. Incomplete removal of AMX during wastewater treatment contributes to its presence in water bodies and drinking water. AMX is an emerging contaminant since its impact on the environment and human health remains uncertain. This contribution was aimed to evaluate the electrochemical oxidation (EO) of AMX using different anodes in tap water, NaCl or Na2SO4 solutions and to evaluate the potential toxicity of remaining AMX and its by-products on zebrafish early-life stages. Chemical intermediates generated after EO were determined by mass spectrometry and their resulting antimicrobial activity was evaluated. AMX did not induce significant mortality in zebrafish during extended exposure but affected zebrafish development (increased body length) from 6.25 mg/L to 25 mg/L and inhibited enzymatic biomarkers. Carbon modified with titanium oxide (TiO2@C) anode achieved complete AMX removal in just a few minutes and efficiency of the supporte...
Source: Chemico-Biological Interactions - Category: Molecular Biology Authors: Tags: Chem Biol Interact Source Type: research