Acid-degradable Dextran as an Image Guided siRNA Carrier for COX-2 Downregulation

Conclusions: We successfully developed an efficient method to produce an acid-degradable dextran nanopolymer containing cleavable amine groups as the siRNA carrier. Because of its biocompatibility, this degradable dextran delivered COX-2 siRNA within tumors and efficiently downregulated COX-2 expression.

Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Zhihang Chen, Balaji Krishnamachary, Marie-France Penet, Zaver M. Bhujwalla Tags: Research Paper Source Type: research