Anti-Inflammatory Action of Sitagliptin and Linagliptin in Doxorubicin Nephropathy

Conclusion: NLRP3 inflammasome activation was shown in our rat model of doxorubicin nephropathy. DPP4 inhibitors can suppress the activity of NLRP3, with or without relieving NADPH oxidase 2-related oxidative stress.Kidney Blood Press Res 2018;43:987 –999
Source: Kidney and Blood Pressure Research - Category: Urology & Nephrology Source Type: research