Vascular Type 1 Angiotensin Receptors Control Blood Pressure by Augmenting Peripheral Vascular Resistance in Female Mice.

Vascular Type 1 Angiotensin Receptors Control Blood Pressure by Augmenting Peripheral Vascular Resistance in Female Mice. Am J Physiol Renal Physiol. 2018 Jun 13;: Authors: Wolf E, Diaz EJ, Hollis A, Hoang TA, Azad HA, Bendt KM, Griffiths RC, Sparks MA Abstract Angiotensin (Ang) II is a major mediator of hypertension pathogenesis. In addition, there are well-documented differences in expression of the renin angiotensin system (RAS) components and Ang II responses between males and females, which may explain sex differences in blood pressure (BP) and hypertension epidemiology. We have previously shown that type 1A Angiotensin (AT1A) receptors in vascular smooth muscle cells (VSMCs) play a critical role in BP regulation and hypertension pathogenesis, but these studies were carried out in male mice. Therefore, the major goal of these studies is to examine the impact of VSMC AT11A receptors on BP and hypertension pathogenesis in female mice. We found that elimination of VSMC AT1A receptors in female mice caused a reduction (≈8 mmHg) in baseline BP without altering sodium sensitivity. The severity of Ang II-dependent hypertension was diminished particularly during the last two weeks of chronic Ang II infusion (≈33% reduction in BP) compared to controls without alterations in natriuresis during the first 5 days of Ang II. Female SMKO mice have enhanced urinary norepinephrine levels compared to controls. There was a virtually complete elimination of...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research

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