Newcastle disease virus: is an updated attenuated vaccine needed?

In conclusion, to confer full protection against NDVs that differ from the vaccine strain at the neutralizing epitopes, very high levels of antibodies should be raised and maintained to compensate for the reduction in the number of effective epitopes; alternatively, an adjusted attenuated vaccine should be developed-a task made possible in the current era of reverse vaccinology. PMID: 29897786 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29897786?dopt=Abstract

Source: Avian Pathology - June 13, 2018 Category: Pathology Authors: Shahar E, Haddas R, Goldenberg D, Lublin A, Bloch I, Bachner Hinenzon N, Pitcovski J Tags: Avian Pathol Source Type: research