Gene expression profiling of breast cancer cell lines treated with proton and electron radiations.

CONCLUSIONS: Here we describe in a detailed way the gene expression profiling and pathways activated after electron and proton irradiation in breast cancer cells. Summarizing, although specific pathways are activated in a radiation type-dependent manner, each cell line activates overall similar molecular networks in response to both these two types of ionizing radiation. Advances in knowledge: In the era of personalized medicine and breast cancer target-directed intervention, we trust that this study could drive radiation therapy towards personalized treatments, evaluating possible combined treatments, based on the molecular characterization.
PMID: 29888960 [PubMed - as supplied by publisher]

Source: The British Journal of Radiology - June 11, 2018 Category: Radiology Authors: Bravatà V, Minafra L, Cammarata FP, Pisciotta P, Lamia D, Marchese V, Manti L, Cirrone GA, Gilardi MC, Cuttone G, Forte GI, Russo G Tags: Br J Radiol Source Type: research