Sema3E/PlexinD1 Inhibition is a Therapeutic Strategy for Improving Cerebral Perfusion and Restoring Functional Loss after Stroke in Aged Rats
Brain tissue survival and functional recovery following ischaemic stroke greatly depend on cerebral vessel perfusion and functional collateral circulation in the ischaemic area. Semaphorin 3E (Sema3E), one of the class 3 secreted semaphorins, has been demonstrated to be a critical regulator in embryonic and postnatal vascular formation via binding to its receptor PlexinD1. However, whether Sema3E/PlexinD1 signalling is involved in poststroke neovascularization remains unknown. To determine the contribution of Sema3E/PlexinD1 signalling to poststroke recovery, aged rats (18 months) were subjected to a transient middle cerebral artery occlusion (tMCAO).
Source: Neurobiology of Aging - Category: Neuroscience Authors: Yi-Fan Zhou, Peng-Cheng Li, Jie-Hong Wu, James Andrew Haslam, Ling Mao, Yuan-Peng Xia, Quan-Wei He, Xu-Xia Wang, Hao Lei, Xiao-Li Lan, Qing Robert Miao, Zhen-Yu Yue, Ya-Nan Li, Bo Hu Source Type: research