Exercise on Hypertension in Chronic Kidney Disease
Condition: Chronic Kidney Diseases Intervention: Behavioral: Exercise Sponsors: University of Alberta; Canadian Institutes of Health Research (CIHR) Not yet recruiting
Conclusion IgAVN in elderly patients is characterized by severe renal involvement. Elderly patients are at higher risk than adults for treatment-related adverse events. PMID: 30101942 [PubMed - as supplied by publisher]
In this issue ofJAMA, Webster and colleagues report the results of the Triple Pill vs Usual Care Management for Patients with Mild-to-Moderate Hypertension (TRIUMPH) pragmatic randomized clinical trial that evaluated the efficacy of a low-dose combination pill containing 20 mg of telmisartan, 2.5 mg of amlodipine, and 12.5 mg of chlorthalidone compared with usual care among 700 adults with hypertension in Sri Lanka. The primary outcome was the proportion of patients whose blood pressure (BP) was controlled at 6 months, which was defined as a systolic/diastolic BP of less than 140/90 mm Hg or less than 130/80 mm Hg among pa...
In conclusion CKD results in the cerebral tissue activation of inflammatory and oxidative pathways, inhibition of antioxidant and cytoprotective system and erosion of cerebral capillary junctional complex, events that contribute to CNS dysfunction and impaired blood brain barrier. PMID: 30093950 [PubMed]
CONCLUSION: CAR at diagnosis can be an independent predictor of all-cause mortality, comparable to DM, the conventional risk factor of mortality. PMID: 30091320 [PubMed - in process]
Conclusion: We found that in patients with CKD, urinary sodium and potassium excretion is closely correlated to renal handling of uric acid, which was pronounced in hypertensive patients with low eGFR. This phenomenon may be one of the mechanisms of the relationship between hypertension and hyperuricemia. Further research is needed to confirm it. It is expected to manage hyperuricemia in terms of controlling the diet of sodium and potassium.Kidney Blood Press Res 2018;43:1310 –1321
ConclusionIt is clear that natural phenolic compounds have some potential inhibitory effect on NADPH oxidase activity. In comparison to other phenolic plant compounds, the structural varability of the flavonoids should off different impacts on oxidative stress in hypertension including inhibition of nadph oxisdase and direct scavenging of free radicals.
Victorine B Nzana, Anusha Rohit, Deepu George, Madhusudan Vijayan, Milly Mathew, Sundar Sankaran, Palaniappan Nagarajan, Georgi AbrahamIndian Journal of Medical Microbiology 2018 36(2):282-284A 51-year-old female, with non-alcoholic liver cirrhosis, portal hypertension, type 2 diabetes mellitus, autosomal dominant polycystic kidney disease with a clipped cerebral aneurysm and chronic kidney disease stage 5 was on continuous ambulatory peritoneal dialysis (CAPD) for 6.5 years elsewhere. She came for opinion on continuation of CAPD as she had 21 episodes of peritonitis in 76 months. Her blood pressure was 80/50 mmHg. She was...
In conclusion, salt induced volume overload in a rat model of CKD had an adverse cardiovascular outcome and it was associated with inflammatory activation and decrease in renal klotho expression. PMID: 30079760 [PubMed - as supplied by publisher]
No abstract available
Purpose of review Small-molecule inhibitors of prolyl hydroxylase domain enzymes (PHD inhibitors) are novel renal anemia therapies that increase endogenous erythropoietin (EPO) production by stabilizing hypoxia-inducible factor (HIF). This review summarizes recent findings and future perspectives of PHD inhibitors (HIF stabilizers) in chronic kidney disease (CKD)-associated anemia. Recent findings Clinical trials have demonstrated that HIF stabilizers effectively increase hemoglobin levels of both nondialysis and dialysis CKD patients without causing serious adverse effects. HIF stabilizers not only restore EPO produc...