Alterations in the stomatognathic system due to amyotrophic lateral sclerosis

Conclusions: ALS may lead to modifications in the activities of the stomatognathic system, including muscular hyperactivity and reduction in chewing efficiency; however, no change has been observed in the masticatory muscle thickness and molar bite force.
Source: Journal of Applied Oral Science - Category: Dentistry Source Type: research

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Many thanks for forwarding the letter from T. Kawada [1] addressing our manuscript on the lack of association between ADHD and ALS in this journal [2]. In principle, the author points out that this topic would deserve further epidemiological studies to come to a more substantiated conclusion. Pathophysiological considerations alone would not suffice to exclude a causal relationship between these two neurodevelopmental and neurodegenerative, respectively, conditions.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research
Ebel et al. evaluated the association between attention-deficit/hyperactivity disorder (ADHD) and amyotrophic lateral sclerosis (ALS) [1]. Sociodemographic factors and physical activities were also considered in the analysis. The authors cited a paper, presenting the hypothesis that there was a pathophysiological link between ADHD and ALS [2], however ALS patients reported a lower prevalence of childhood ADHD and there was no evidence that ADHD had been more common in ALS patients. I have 2 concerns about this study.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research
by Michael D. Ehlers, MD, PhD Dr. Ehlers is with Biogen in Cambridge, Massachusetts. Innov Clin Neurosci. 2018;15(3–4):15–16 Funding: No funding was received for the preparation of this article. Disclosures: Dr. Ehlers is an employee and shareholder at Biogen Inc. in Cambridge, Massachusetts. Prominent and expensive failures in Alzheimer’s disease therapies have led to a contagious belief system in some parts of the biopharma industry that neuroscience is just too hard, too risky, and too uncertain. But, might this belief system itself be a residual bias of the past? Close inspection reveals all the signs...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Commentary Current Issue Source Type: research
Lul é, Ludolph, and Ludolph (2008) [1] hypothesized that there may be a pathophysiological link between attention-deficit/hyperactivity disorder (ADHD) and amyotrophic lateral sclerosis (ALS). They summarized common clinical features, specifically enhanced physical and psychological activity, which hav e been described typically for ADHD patients and also as common personality traits before disease onset in patients with ALS.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Source Type: research
Publication date: November 2017 Source:The Journal of Steroid Biochemistry and Molecular Biology, Volume 174 Author(s): Maria Meyer, Laura I. Garay, María Sol Kruse, Agustina Lara, Gisella Gargiulo-Monachelli, Michael Schumacher, Rachida Guennoun, Hector Coirini, Alejandro F. De Nicola, Maria Claudia Gonzalez Deniselle Amyotrophic lateral sclerosis (ALS) is a devastating disorder characterized by progressive death of motoneurons. The Wobbler (WR) mouse is a preclinical model sharing neuropathological similarities with human ALS. We have shown that progesterone (PROG) prevents the progression of motoneuron degenerat...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Abstract Alongside the best-known applications of brain-computer interface (BCI) technology for restoring communication abilities and controlling external devices, we present the state of the art of BCI use for cognitive assessment and training purposes. We first describe some preliminary attempts to develop verbal-motor free BCI-based tests for evaluating specific or multiple cognitive domains in patients with Amyotrophic Lateral Sclerosis, disorders of consciousness, and other neurological diseases. Then we present the more heterogeneous and advanced field of BCI-based cognitive training, which has its roots in ...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
CONCLUSION: Clinical trials with strong methodologies and appropriate doses of melatonin are necessary to support or reject the usefulness of melatonin in neurological diseases. PMID: 28721826 [PubMed - as supplied by publisher]
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research
Authors: Grapperon AM, Attarian S Abstract Neuronal and/or axonal hyperactivity and hyperexcitability is an important feature of motor neuron diseases. It results clinically in cramps and fasciculations. It is not specific to motor neuron diseases, and can occur in healthy subjects, as well as in various pathologies of the peripheral nervous system, including nerve hyperexcitability syndromes. Hyperexcitability plays an important and debated role in the pathophysiology of motor neuron diseases, especially in amyotrophic lateral sclerosis (ALS). The mechanisms causing hyperexcitability are not yet clearly identified...
Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
In this study, we established a steroid profiling in brain, spinal cord, plasma, adrenal glands, and testes in 2-month-old male Wobbler mice and their littermates by gas chromatography coupled to mass spectrometry. Our results show in Wobbler mice the following: 1) a marked up-regulation of corticosterone levels in adrenal glands, plasma, spinal cord regions (cervical, thoracic, lumbar) and brain; 2) a strong decrease in T levels in the testis, plasma, spinal cord, and brain; and 3) increased levels of progesterone and especially of its reduced metabolites 5α-dihydroprogesterone, allopregnanolone, and 20α-dihyd...
Source: Endocrinology - Category: Endocrinology Authors: Tags: Endocrinology Source Type: research
In this study, we established a steroid profiling in brain, spinal cord, plasma, adrenal glands and testes in two months-old male Wobbler mice and their littermates by gas chromatography coupled to mass spectrometry. Our results show in Wobbler mice i) a marked upregulation of corticosterone levels in adrenal glands, plasma, spinal cord regions (cervical, thoracic, lumbar) and brain, ii) a strong decrease in testosterone levels in testis, plasma, spinal cord and brain, and iii) increased levels of progesterone and especially of its reduced metabolites 5α-dihydroprogesterone, allopregnanolone and 20α-dihydroprog...
Source: Endocrinology - Category: Endocrinology Authors: Tags: Endocrinology Source Type: research
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