Predictors of Patient-Reported Dysphagia Following IMRT Plus Chemotherapy in Oropharyngeal Cancer

AbstractThe aim of this cross-sectional study is to evaluate the factors associated with patient-reported dysphagia in patients affected by locally advanced oropharyngeal cancer (OPC) treated with definitive intensity-modulated radiation therapy (IMRT) and concurrent chemotherapy (CHT), with or without induction CHT. We evaluated 148 OPC patients treated with IMRT and concurrent CHT, without evidence of disease and who had completed their treatment since at least 6  months. At their planned follow-up visit, patients underwent clinical evaluation and completed the M.D. Anderson dysphagia inventory (MDADI) questionnaire. The association between questionnaire composite score (MDADI-CS) and different patients’ and tumor’s characteristics and treatments (covar iates) was investigated by univariable and multivariable analyses, the latter including only covariates significant at univariable analysis. With a median time from treatment end of 30 months [range 6–74 months, interquartile range (IQR) 16–50 months], the median (IQR) MDADI-CS was 72 (63–8 4). The majority of patients (82.4%) had a MDADI-CS ≥ 60. At multivariable analysis, female gender, human papilloma virus (HPV)-negative status, and moderate and severe clinician-rated xerostomia were significantly associated with lower MDADI-CS. Patient-perceived dysphagia was satisfactory or acceptable in the majority of patients. HPV status and xerostomia were confirmed...
Source: Dysphagia - Category: Speech-Language Pathology Source Type: research

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Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research
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Abstract ObjectivesTo analyze survival and toxicity outcomes in patients treated with primary intensity‐modulated radiotherapy (IMRT) for oropharyngeal squamous cell carcinoma (OPSCC) in the era of routine human papilloma virus (HPV) testing. DesignSingle institution case series. SettingTertiary Head and Neck Cancer Unit Participants186 patients who received IMRT (+/‐ chemotherapy) for radical primary treatment of OPSCC between March 2010 and December 2013. HPV status was available for 88% of cases. Median radiation dose was 65Gy in 30 daily fractions. 90% of stage III/IV patients received concurrent chemotherapy or ce...
Source: Clinical Otolaryngology - Category: ENT & OMF Authors: Tags: Original Article Source Type: research
More News: Cancer | Cancer & Oncology | Chemotherapy | Human Papillomavirus (HPV) | Intensity-Modulated Radiation Therapy | Oropharyngeal Cancer | Radiation Therapy | Speech-Language Pathology | Study | Xerostomia