Widespread uranium contamination found in India's groundwater
(Duke University) A Duke-led study has found widespread uranium contamination in groundwater aquifers -- a chief source for drinking water and irrigation -- in 16 Indian states. The primary source of the contamination is natural, but human factors such as groundwater-table depletion and nitrate pollution may exacerbate the problem. Studies have linked exposure to uranium in drinking water to chronic kidney disease.
ConclusionsOur results provide evidence that PROMIS-57 and PROMIS-29 are highly reliable and valid instruments among kidney transplant recipients. We propose it as a valuable tool to assess important domains of the illness experience.
Conclusions: Our data indicate that higher TSH concentrations are positively correlated with CKD prevalence and that a high TSH concentration is a risk factor for CKD development.Nephron
Publication date: Available online 21 February 2019Source: American Journal of Kidney DiseasesAuthor(s): Vimal K. Derebail, Emily J. Ciccone, Qingning Zhou, R. Rosina Kilgore, Jianwen Cai, Kenneth I. AtagaRationale &ObjectiveProgression of chronic kidney disease (CKD) in sickle cell disease (SCD) and its risk factors remain poorly defined. We identified characteristics associated with CKD as well as decline in estimated glomerular filtration rate (eGFR) and presence of proteinuria over time in adults with SCD.Study DesignRetrospective observational study.Setting &ParticipantsPatients with SCD 18 years or older in a...
ConclusionsCKD stage 3 was not associated with an increase in fracture status. QUS parameters were similarly associated with fracture status in patients with and without CKD.
DISCUSSION: Physical activity, diet, body mass index, the presence of diabetes, and the presence of chronic kidney disease were strong risk factors for hypertension. Many of these risk factors are modifiable and highlight targets for future prevention strategies. PMID: 30785634 [PubMed - in process]
Circulating C3 has been associated with diabetes and hypertension, which are the leading causes of chronic kidney disease (CKD). C3 activation is considered to contribute to several renal diseases. Here we exa...
Publication date: Available online 19 February 2019Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Laura Ferreras, Anna Moles, Gerhard R. Situmorang, Rana el Masri, Imogen L. Wilson, Katie Cooke, Emily Thompson, Marion Kusche-Gullberg, Romain R. Vivès, Neil S. Sheerin, Simi AliAbstractOne of the main feature of chronic kidney disease is the development of renal fibrosis. Heparan Sulfate (HS) is involved in disease development by modifying the function of growth factors and cytokines and creating chemokine gradients. In this context, we aimed to understand the function of HS sulfation in rena...
Condition: Chronic Kidney Diseases Interventions: Behavioral: PRO-based follow-up; Behavioral: PRO-based telephone consultation Sponsors: University of Aarhus; Regional Hospital West Jutland; Aarhus University Hospital; TrygFonden, Denmark; Karen Elise Jensen Foundation; Sygekassernes Helsefond Active, not recruiting
Nephrons scar and involute during aging, increasing the risk of chronic kidney disease. Little is known, however, about genetic mechanisms of kidney aging. We sought to define the signatures of age on the renal transcriptome using 563 human kidneys. The initial discovery analysis of 260 kidney transcriptomes from the TRANScriptome of renaL humAn TissuE Study (TRANSLATE) and the Cancer Genome Atlas identified 37 age-associated genes. For 19 of those genes, the association with age was replicated in 303 kidney transcriptomes from the Nephroseq resource.
Tubulointerstitial fibrosis is considered a hallmark of maladaptive repair processes after tubular injury leading to chronic kidney disease. Nakamura and colleagues show that, upon injury, myofibroblasts promote epithelial repair by producing retinoic acid in place of injured tubular cells. These results suggest that resident fibroblasts turning into myofibroblasts maintain a cross-talk that protects tubular epithelial cells from injury and can restore tissue integrity and functionality, challenging the concept that fibrosis is only detrimental in nature.