Widespread uranium contamination found in India's groundwater

(Duke University) A Duke-led study has found widespread uranium contamination in groundwater aquifers -- a chief source for drinking water and irrigation -- in 16 Indian states. The primary source of the contamination is natural, but human factors such as groundwater-table depletion and nitrate pollution may exacerbate the problem. Studies have linked exposure to uranium in drinking water to chronic kidney disease.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Authors: Gorostidi M, Sánchez-Martínez M, Ruilope LM, Graciani A, de la Cruz JJ, Santamaría R, Del Pino MD, Guallar-Castillón P, de Álvaro F, Rodríguez-Artalejo F, Banegas JR Abstract BACKGROUND: Chronic kidney disease (CKD) is a public health problem worldwide. We aimed to estimate the CKD prevalence in Spain and to examine the impact of the accumulation of cardiovascular risk factors (CVRF). MATERIAL AND METHODS: We performed a nationwide, population-based survey evaluating 11,505 individuals representative of the Spanish adult population. Information was collected th...
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - Category: Urology & Nephrology Tags: Nefrologia Source Type: research
Background: Chronic Kidney Disease (CKD) is a major public health problem and is increasingly being recognized as an important driver of costs in all health care systems. The diversity of outcomes for people living with CKD is in part due to variability in biology, access to care, environmental factors, and health care system differences. The International Society of Nephrology (ISN), working in collaboration with its partners, has evolved into a philanthropic organization, from a traditional medical society, committed to a vision that sees “a future where all people have access to sustainable kidney health”. A...
Source: Annals of Nutrition and Metabolism - Category: Nutrition Source Type: research
Background: Type 2 diabetes, chronic kidney disease (CKD) and its cardiovascular complications are increasing as health problems worldwide. These diseases are interrelated with overlapping occurrence and once diabetes is established, the risk of cardiorenal disease is dramatically elevated. Thus, a search for unifying modifiable risk factors is key for effective prevention.Summary: Elevated fasting plasma concentration of vasopressin, measured with the marker copeptin, predicts new onset type 2 diabetes as well as renal function decline. Furthermore, we recently showed that increased plasma copeptin concentration independe...
Source: Annals of Nutrition and Metabolism - Category: Nutrition Source Type: research
Background: Diabetic nephropathy has become the most common cause of chronic kidney disease (CKD). Despite the progress accomplished in therapy, the prevalence of renal disorders remains high. Some modifiable factors driving the increase in incidence of CKD, in diabetes and other settings, might have been overlooked. Consistent evidence supports a role for vasopressin, hydration state, and urine concentration in kidney health.Summary: Plasma vasopressin is elevated in diabetes, even if metabolic control is good. Several epidemiological studies have pointed to a positive association between markers of vasopressin secretion ...
Source: Annals of Nutrition and Metabolism - Category: Nutrition Source Type: research
The risk assessment tool from the recent Kidney Disease: Improving Global Outcomes conference adds another prediction model for the risk of developing advanced chronic kidney disease and potential need for dialysis.1 None of the existing prediction models use a patient ’s rate of loss of estimated glomerular filtration rate (eGFR). Both current eGFR and the magnitude of past eGFR decline contribute substantially to the risk of end-stage renal disease.2 Furthermore, a graph of all previous eGFR values is an effective visual aid for shared decision-making and can be a useful predictor of when clinical events and treatm...
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research
Fibroblast growth factor 23 (FGF23) has appeared as a hormone that is massively elevated in patients with chronic kidney disease. Whether FGF23 is a risk factor that associates with cardiac pathologies and cardiovascular mortality, as suggested by a variety of clinical studies, or additionally acts as a causative factor that induces cardiac injury, as more recently indicated by cell culture and animal studies, is under debate and the center of many ongoing experimental studies.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Commentary Source Type: research
Vascular calcification is a frequent complication of advanced chronic kidney disease. Protein carbamylation is implicated in the acceleration of vascular disease in chronic kidney disease, but the mechanisms are not  clear. Mori et al. report that protein carbamylation exacerbates vascular calcification by decreasing ectonucleotide pyrophosphate/phosphodiesterase 1 expression, owing to carbamylation of mitochondrial proteins and oxidative stress. This provides new insight into the pathways responsible for cal cification in chronic kidney disease.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Commentary Source Type: research
Publication date: Available online 19 June 2018 Source:Nitric Oxide Author(s): Xiaoong Liu, Xin Xu, Ruru Shang, Yingjie Chen Patients with chronic kidney disease have an increased cardiovascular morbidity and mortality. It has been recognized that the traditional cardiovascular risk factors could only partially explain the increased cardiovascular morbidity and mortality in patients with chronic kidney disease. Asymmetric dimethylarginine (ADMA) and N-monomethy l-arginine (L-NMMA) are endogenous inhibitors of nitric oxide synthases that attenuate nitric oxide production and enhance reactive oxidative specie generation. In...
Source: Nitric Oxide - Category: Chemistry Source Type: research
Patients with chronic kidney disease (CKD) are predisposed to heart rhythm disorders, including atrial fibrillation (AF)/flutter, supraventricular tachycardias, ventricular arrhythmias, and sudden cardiac death (SCD). This population is also historically underrepresented in clinical trials of treatment for heart rhythm disorders.1
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Digest Source Type: research
International Journal of Urology, EarlyView.
Source: International Journal of Urology - Category: Urology & Nephrology Authors: Source Type: research
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