IGFBP2 promotes salivary adenoid cystic carcinoma metastasis by activating the NF- κB/ZEB1 signaling pathway

In this study, we identified that IGFBP2, overexpressed in SACC, correlated positively with perineural invasion or metastasis and indicated worse outcome. Moreover, IGFBP2 overexpression could dramatically improve motility and invasion capacity of SACC cells in vitro. Mechanically, IGFBP2 enhanced expression of ZEB1 in a NF- κB (p65)-dependent manner and then promoted epithelial-mesenchymal transition (EMT) in SACC.

Source: Cancer Letters - June 6, 2018 Category: Cancer & Oncology Authors: Xiaofeng Yao, Yu Wang, Yuansheng Duan, Qiang Zhang, Ping Li, Rui Jin, Yingjie Tao, Wenchao Zhang, Xudong Wang, Chao Jing, Xuan Zhou Tags: Original Articles Source Type: research