Activities of oxadiazole antibacterials against Staphylococcus aureus and other Gram-positive bacteria.

Activities of oxadiazole antibacterials against Staphylococcus aureus and other Gram-positive bacteria.
Antimicrob Agents Chemother. 2018 Jun 04;:
Authors: Ceballos S, Kim C, Ding D, Mobashery S, Chang M, Torres C
Abstract
The activities of four oxadiazoles were investigated with 210 methicillin-resistant Staphylococcus aureus (MRSA) strains. MIC50 and MIC90 values of 1-2 and 4 μg/ml, respectively, were observed. We also evaluated the activity of oxadiazole ND-421 against other staphylococci and enterococci and in the presence of oxacillin for selected MRSA. The MIC for ND-421 is lowered several fold in combination with oxacillin, as they synergize. The MIC90 of ND-421 against vancomycin-resistant enterococci (VRE) is ≤1 μg/ml.
PMID: 29866865 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - June 4, 2018 Category: Microbiology Authors: Ceballos S, Kim C, Ding D, Mobashery S, Chang M, Torres C Tags: Antimicrob Agents Chemother Source Type: research