Evaluation of renal function by 99mTc-DTPA renal dynamic imaging in different stages of polycystic kidney disease

Conclusions:The renal dynamic imaging and Gate’s method can evaluate the renal function in the early stage of polycystic renal disease (CKD1~3 stage) effectively, and suitable renogram of double kidneys could be also obtained. But it is not appropriate in the late stage (CKD4~5 stage). These results may be due to the following reasons: 1. With the increase of the volume and amount of unfunctional vesicles, more and more normal kidneys are squeezed and atrophied. When outlining the ROI of the kidney, the actual boundaries of the kidneys are not clear, so the ROI of the kidney was easy to be oversize and overestimate GFR in stage CKD4~5 stage [GFR<30ml/(min·1.73m2)]. 2. Most of the patients combined with polycystic liver and polycystic spleen, some kidney tissues overlap with the liver and spleen on the front-back positions. When outlining the ROI of the kidney, it is inevitable that a part of the liver or spleen region will be included, which in turn overestimates GFR. 3. With the progress of the disease, polycystic kidney depth has changed, which will have an impact on the accuracy of GFR. Key words: Polycystic Kidney Diseases; Glomerular filtration rate; Renal dynamic imaging; Gate’s method; Table 1 Comparison of the GFR values measured by renal dynamic imaging and double plasma methodGroupCasedGFR(min ⢠1.73 m2)gGFR(min ⢠1.73 m2)Paired t-testCorrelation analysist valueP valuet valueP valueA1980.58±16.275.39±20.751...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Renal/Hypertension Source Type: research