Current Neural and Behavioral Dimensional Constructs Across Mood Disorders

We present an integrated model for conceptualizing and understanding mood disorders drawing upon a broad literature. This integrated model of emotion processing and regulation incorporates the linguistic constructs of the Research Domain Criteria (RDoC) initiative. In particular, we focus on the positive valence domain/circuit (PVC), highlighting recent reward research and the negative valence domain/circuit (NVC), highlighting rumination. Furthermore, we also illustrate the Cognitive Control and Problem Solving (CCaPS) circuit, which is heavily involved in emotion regulation, as well as the default mode network (DMN) and interactions between circuits. We conclude by proposing methods for addressing challenges in the developmental study of mood disorders, including using high-risk design that incorporates risk for many disorders.
Source: Current Behavioral Neuroscience Reports - Category: Neuroscience Source Type: research