Incorporation of nanoparticles into transplantable decellularized matrices: Applications and challenges.

Incorporation of nanoparticles into transplantable decellularized matrices: Applications and challenges. Int J Artif Organs. 2018 May 01;:391398818775522 Authors: Saleh TM, Ahmed EA, Yu L, Kwak HH, Hussein KH, Park KM, Kang BJ, Choi KY, Kang KS, Woo HM Abstract Decellularization of tissues can significantly improve regenerative medicine and tissue engineering by producing natural, less immunogenic, three-dimensional, acellular matrices with high biological activity for transplantation. Decellularized matrices retain specific critical components of native tissues such as stem cell niche, various growth factors, and the ability to regenerate in vivo. However, recellularization and functionalization of these matrices remain limited, highlighting the need to improve the characteristics of decellularized matrices. Incorporating nanoparticles into decellularized tissues can overcome these limitations because nanoparticles possess unique properties such as multifunctionality and can modify the surface of decellularized matrices with additional growth factors, which can be loaded onto the nanoparticles. Therefore, in this minireview, we highlight the various approaches used to improve decellularized matrices with incorporation of nanoparticles and the challenges present in these applications. PMID: 29807488 [PubMed - as supplied by publisher]
Source: The International Journal of Artificial Organs - Category: Transplant Surgery Authors: Tags: Int J Artif Organs Source Type: research