Molecules, Vol. 23, Pages 1277: N-oxide alkaloids from Crinum amabile (Amaryllidaceae)

In this study, twenty-three alkaloids were identified from Crinum amabile by GC-MS and two new structures (augustine N-oxide and buphanisine N-oxide) were structurally elucidated by NMR. Anti-parasitic and cholinesterase (AChE and BuChE) inhibitory activities of six alkaloids isolated from this species, including the two new compounds, are described herein. None of the alkaloids isolated from C. amabile gave better results than the reference drugs, so it was possible to conclude that the N-oxide group does not increase their therapeutic potential.

Source: Molecules - May 26, 2018 Category: Chemistry Authors: Luciana R. Tallini Laura Torras-Claveria Warley de Souza Borges Marcel Kaiser Francesc Viladomat Jos é Angelo S. Zuanazzi Jaume Bastida Tags: Article Source Type: research