Curvilinear locus coeruleus functional connectivity trajectories over the adult lifespan: a 7T MRI study

The locus coeruleus (LC) plays a crucial role in modulating several higher-order cognitive functions via its widespread projections to the entire brain. We set out to investigate the hypothesis that LC functional connectivity (FC) may fluctuate non-linearly with age and explored its relation to memory function. To that end, forty-nine cognitively healthy individuals (19-74 years) underwent ultra high-resolution 7T resting-state fMRI and cognitive testing. FC patterns from the LC to regions of the isodendritic core network and cortical regions were examined using ROI-to-ROI analyses.
Source: Neurobiology of Aging - Category: Neuroscience Authors: Source Type: research