Lessons learned from the PRESERVE trial.
Lessons learned from the PRESERVE trial.
Br J Radiol. 2018 May 17;:20180092
Authors: Partovi S, Trischman T, Kang PS
Abstract
The recently published PRESERVE trial is presently the largest and most comprehensive clinical trial comparing commonly applied strategies for prevention of iodinated contrast-induced acute kidney injury in high-risk patients. The fundamental conclusion of the PRESERVE trial is that oral acetylcysteine and intravenous sodium bicarbonate are not superior to simple intravenous hydration with isotonic saline for the prevention of contrast-induced renal sequelae. In this commentary, we discuss the results in the context of selected past major trials, and provide insights into the strengths and potential weaknesses of the PRESERVE trial. In the future, developing individualized preventive approaches to avoid contrast-induced acute kidney injury for different patient populations is recommended.
PMID: 29770709 [PubMed - as supplied by publisher]
Source: The British Journal of Radiology - Category: Radiology Authors: Partovi S, Trischman T, Kang PS Tags: Br J Radiol Source Type: research
More News: Acetylcysteine | Clinical Trials | Lessons | Radiology | Sodium | UK Health | Urology & Nephrology