Neuroprotective effects of cryptotanshinone and 1,2-dihydrotanshinone I against MPTP induced mouse model of Parkinson ’s disease

Publication date: August 2018 Source:Phytochemistry Letters, Volume 26 Author(s): Gui-yun Cao, Xiao-hong Wang, Ke-ke Li, Ai-hong Zhao, Li Shen, Duo-nan Yu 1,2-dihydrotanshinone I (DTs1) and cryptotanshinone (CTs) are the two major compounds isolated from Salvia castanea f. tomentosa Stib., which possess diverse biological effects such as antioxidant, anticancer, anti-​atherogenic, anti-​hepatic fibrosis. However, there is no any report available on the neuroprotective effects of DTs1 and CTs against MPTP induced dopaminergic neurons damage. Therefore, in this study, we investigated the neuroprotective effects of DTs1 and CTs in the MPTP-induced PD model of C57BL/6 mice. Locomotor behavior, tyrosine hydroxylase (TH) protein expression indicated that DTs1 and CTs significantly improved TH expression, inhibited dopaminergic cell loss induced by MPTP. Biochemical parameters determination and real-time polymerase chain reaction (PCR) analysis revealed that DTs1 and CTs increased the activities and mRNA expressions of Superoxide Dismutase (SOD), Glutathione peroxidase (GSH-Px), Catalase (CAT), deceased the level of Malondialdehyde (MDA). These findings indicated that DTs1 and CTs showed neuroprotective effects in MPTP-induced PD mice, which might be associated with their antioxidant properties. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research

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Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured health and fitness productivity tips food for brain food for the mind foods that make your smarter productive productive people Source Type: blogs
In a presentation Tuesday at the XXIV World Congress of Neurology in Dubai, researchers from the Center for Neurodegenerative Science at Van Andel Institute in Grand Rapids, Mich., told more than 4,000 neurologists.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
Condition:   Parkinson's Disease Intervention:   Biological: AAV2-GDNF Sponsor:   Brain Neurotherapy Bio, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Parkinson's Hallucinations Intervention:   Drug: Ondansetron 8mg or matched placebo Sponsors:   University College, London;   MODEPHARMA Limited;   PARKINSONS UK;   PRIMENT;   SEALED ENVELOPE;   Wasdell Packaging Ltd;   Custom Pharmaceuticals Limited Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Parkinson's Disease Intervention:   Biological: AAV2-GDNF Sponsor:   Brain Neurotherapy Bio, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSION: As it is detected by a survey performed by telephone calls with good interrater reliability, patients with PD gets better with LCIG treatment in many aspects of the disease. PMID: 31731332 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Publication date: Available online 18 November 2019Source: The Lancet NeurologyAuthor(s): John F Cryan, Kenneth J O'Riordan, Kiran Sandhu, Veronica Peterson, Timothy G DinanSummaryResearch into the role of the gut microbiome in modulating brain function has rapidly increased over the past 10 years, albeit chiefly in animal models. Increasing clinical and preclinical evidence implicates the microbiome as a possible key susceptibility factor for neurological disorders, including Alzheimer's disease, autism spectrum disorder, multiple sclerosis, Parkinson's disease, and stroke. Cross-sectional clinical studies are bolstering ...
Source: The Lancet Neurology - Category: Neurology Source Type: research
Abstract About 10 years ago, the so-called chronic cerebrospinal venous insufficiency syndrome was discovered. This clinical entity, which is associated with extracranial venous abnormalities that impair venous outflow from the brain, was initially found exclusively in multiple sclerosis patients. Currently, we know that such venous lesions can also be revealed in other neurological pathologies, including Alzheimer's and Parkinson's diseases. Although direct causative role of chronic cerebrospinal venous insufficiency in these neurological diseases still remains elusive, in this paper, we suggest that perhaps an a...
Source: Reviews on Recent Clinical Trials - Category: Cancer & Oncology Authors: Tags: Rev Recent Clin Trials Source Type: research
Publication date: Available online 18 November 2019Source: World Journal of Acupuncture - MoxibustionAuthor(s): Yu-hua ZHAOAbstractIn this article, one proved case of flaccid tongue treated by Guan's tongue acupuncture was introduced by the three-step method of “puncture, prick, and swallowing”. This case was an elderly female patient with Parkinson disease, which had the main clinical symptoms of flaccid and weak tongue, and speech and swallowing disorder, and was diagnosed as flaccid tongue (deficiency of the both qi and blood, and deficiency syndrome of liver and kidney). The patient received diagnosis and t...
Source: World Journal of Acupuncture Moxibustion - Category: Complementary Medicine Source Type: research
(San Diego State University) Carbon electrodes will last longer than metal when embedded in the brain of patients with Parkinson's and tremors, and won't be affected by MRI.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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