Chitosan-coated C-phycocyanin liposome for extending the neuroprotective time window against ischemic brain stroke.

This study sought to verify if muco-adhesive chitosan coating improves the neuroprotective potential of the pre-proven C-Phycocyanin-pertaining liposome (C-Pc liposome). The use of chitosan-coated liposomes extended the neuroprotective time window by 6 h after reperfusion, and further improved the neuroprotection efficiency of the C-Pc liposome in a rat middle cerebral artery occlusion (MCAO) model. Beneficial changes in mRNA expressions of antioxidants, inflammatory cytokines and glia scar proteoglycans were evident in the C-Pc liposomes. In addition, in the cultured astrocytes, the chitosan-coated C-Pc liposome expressed anti-oxidative activity without cytotoxicity. PMID: 29766794 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research