ALDH2 Protects Against Ischemic Stroke in Rats by Facilitating 4-HNE Clearance and AQP4 Down-Regulation.

In conclusion, increasing ALDH2 activity can improve brain edema, infarct volumes, and reduce neurological impairment in a rat IS model. The therapeutic benefits of ALDH2 are related to 4-HNE clearance and AQP4 down-regulation. PMID: 29767275 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29767275?dopt=Abstract

Source: Neurochemical Research - May 16, 2018 Category: Neuroscience Authors: Li Y, Liu SL, Qi SH Tags: Neurochem Res Source Type: research