8. An evidence-based approach to guide IGH-based reflex testing for plasma cell neoplasms

FISH testing for plasma cell neoplasms is a common bottleneck in laboratory workflows. CD138+ enrichment is often required to improve sensitivity, yet still may yield insufficient or poor quality cells, and possibly, false negative results. Our current Multiple Myeloma panel (MMP) is designed as a reflex test, in which IGH break-apart (IGH-BAP) and t(11;14) results direct subsequent testing for t(4;14) and t(14;16). While cost-effective, this strategy can be problematic, particularly for CD138+ sorted samples.

Source: Cancer Genetics and Cytogenetics - May 17, 2018 Category: Genetics & Stem Cells Authors: Jodi Zockle, Brandon Chandler, Karen Delgado, Denise Quigley, Reha Toydemir, Erica Andersen Source Type: research