The application of natural products in cancer therapy by targeting apoptosis pathways.

The application of natural products in cancer therapy by targeting apoptosis pathways. Curr Drug Metab. 2018 May 11;: Authors: Wang Y, Zhong J, Bai J, Tonga R, An F, Jiao P, He L, Zeng D, Long E, Yan J, Yu J, Cai L Abstract Apoptosis is one of the pathways of programmed cell death (PCD), which leads to pathognomic cellular changes different from cellular necrosis. It includes the death receptor pathway and the mitochondrial pathway, both of which involve many key proteins, including cytochrome c, Fas, the Bcl-2 family, caspases, survivin and p53. In apoptosis-related diseases, such as cancer, many proteins associated with apoptosis are abnormally expressed. The majority of anti-cancer agents promote apoptosis to induce cancer cell death. Furthermore, numerous natural products have been reported to induce the cell apoptosis by regulating the expression of key apoptotic proteins, leading to a variety of anti-tumor effects. In this review, we aim to survey the current knowledge on key apoptotic proteins and some representative natural products that can induce cancer cell apoptosis by regulating these proteins. PMID: 29749309 [PubMed - as supplied by publisher]
Source: Current Drug Metabolism - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Metab Source Type: research