A case of epidural glioblastoma metastasis presenting with a cervical myelopathy, torticollis, and L ’hermitte’s phenomenon

AbstractExtraneural glioblastoma metastases are exceedingly rare, though previously described in the literature. Activating mutations in theBRAF kinase gene (V600E) are present in a minority of glioblastoma patients. Here, we describe a case of systemic metastases of a clonal subpopulation ofBRAF V600E mutated glioblastoma in a patient previously treated with surgery, radiation, temozolomide and bevacizumab. The patient presented with a subacute cervical myelopathy during adjuvant treatment. He underwent emergent surgical decompression of an epidural spine metastasis. Analysis of the metastatic tumor demonstrated clonal expansion of aBRAF V600E subpopulation. Though rare, systemic metastasis of glioblastoma should be considered in patients presenting with subacute complaints in line with a mass lesion.
Source: Brain Tumor Pathology - Category: Neurology Source Type: research