Stable olfactory sensory neuron in vivo physiology during normal aging

Normal aging is associated with a number of smell impairments that are paralleled by age-dependent changes in the peripheral olfactory system, including decreases in olfactory sensory neurons (OSNs) and in the regenerative capacity of the epithelium. Thus, an age-dependent degradation of sensory input to the brain is one proposed mechanism for the loss of olfactory function in older populations. Here, we tested this hypothesis by performing in vivo optical neurophysiology in 6, 12, 18, and 24 month-old mice.
Source: Neurobiology of Aging - Category: Neuroscience Authors: Tags: Negative results Source Type: research