The total number of myelinated nerve fibers is reduced in corpus callosum in brains from patients with Alzheimer ´s disease

We have estimated the total number of myelinated fibers in corpus callosum (CC) from brains of Alzheimer patients and control subjects using a two-dimensional fractionator principle. The total number of fibers in ten females Alzheimer patients (AD) (mean age 82.8 years) and twelve female control subjects (mean age 80.6 years) showed the mean number of myelinated fibers was significantly 30% higher in the control group (90.0x106; coefficient of variation (CV)=SD/mean=27%) than in the AD group (69.3x106; CV=20%) (p=0.028).
Source: Neurobiology of Aging - Category: Neuroscience Authors: Source Type: research