Influence of 6 genetic variants on the efficacy of statins in patients with dyslipidemia
Journal of Clinical Laboratory Analysis, EarlyView.
The optimal management of patients with asymptomatic carotid stenosis (ACS) is controversial. The study by Klarin et al1 provides important novel information that challenges the theory claiming that medical treatment (MT) alone is adequate for the management of all patients with ACS and that prophylactic carotid endarterectomy is not justified in any of these patients.2 Klarin et al1 showed that 112 of 219 pat ients (50%) with radiographically confirmed first-ever carotid-related strokes did actually receive antiplatelet therapy before their stroke, and 121 of 219 patients (55%) received lipid-low...
New drugs that lower levels of triglycerides (a type of fat) in blood could further reduce the risk of heart attack when added to statins, according to new research conducted by MRC scientists.
Analysis of NHANES data showed no overall benefit of statins for primary prevention, with the exception of adults with type 2 diabetes, and only for those aged 75 to 84 years.Medscape Medical News
Cambridge University researchers tested the effects of LPL enhancers using genetic data of around 400,000 people. The results were published in JAMA Cardiology.
THERE is no evidence that high levels of “bad” cholesterol cause heart disease and the widespread use of statins is “of doubtful benefit”, according to a study by 17 international physicians.
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy,Volume 0, Issue ja, -Not available-.
Diabetes, Obesity and Metabolism,Volume 0, Issue ja, -Not available-.
Background: The development of cirrhosis with resultant portal hypertension can lead to oesophageal varices at a rate of 7% per annum. Bleeding from varices happens when the portal pressure is ≥12 mm Hg and can threaten life.Summary: Eliminating the aetiology of cirrhosis is a pivotal step to prevent the formation of varices. In patients with established varices, primary prophylaxis with non-selective beta blockers (NSBB) may slow down the progression of varices and prevent the first variceal bleed. NSBB, similar to other agents such as renin/angiotensin blockers, statins, and rifaximin, may have the additional advantag...