Influence of 6 genetic variants on the efficacy of statins in patients with dyslipidemia

Journal of Clinical Laboratory Analysis, EarlyView.
Source: Journal of Clinical Laboratory Analysis - Category: Laboratory Medicine Authors: Source Type: research

Related Links:

Authors: Dayanand P, Sandhyavenu H, Dayanand S, Martinez J, Rangaswami J Abstract Vascular calcification is known to be a strong risk factor for cardiovascular adverse events and mortality. Atherosclerosis, diabetes, aging, abnormal bone mineral homeostasis and high uremic milieu such as chronic kidney disease are major factors that contribute to the progression of vascular calcification. Several mechanisms such as the osteoblastic transition of vascular smooth muscle cells in response to oxidative stress have shed light on the active nature of vascular calcification, which was once thought to be a passive process....
Source: Current Cardiology Reviews - Category: Cardiology Tags: Curr Cardiol Rev Source Type: research
(MedPage Today) -- Mendelian'randomization'suggests potential for benefit on par with statin
Source: MedPage Today Primary Care - Category: Primary Care Source Type: news
Conclusion: Experimental studies revealed the antineoplastic efficacy of statins but statins were associated with thyroid carcinoma in clinical studies. This discrepancy may be due to the different concentrations of statins used and the effects of hyperlipidemia interventions, and thus further study is required.Cell Physiol Biochem 2018;47:1422 –1431
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
The Dutch College of General Practitioners' guideline on peripheral arterial disease (PAD) provides clear recommendations on the management of PAD. An ankle brachial index (ABI) measurement, prescription of antiplatelet drugs and statins, and supervised exercise therapy (SET) for intermittent claudication (IC) are advised. The aims of this study were to determine the adherence of general practitioners (GPs) to their own guideline on PAD and to evaluate the reliability of primary care ABI measurements.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Selected Abstract from the June Issue of the European Journal of Vascular and Endovascular Surgery Source Type: research
Publication date: Available online 20 June 2018 Source:Pharmacological Research Author(s): Fatemeh Forouzanfar, Alexandra E. Butler, Maciej Banach, George E. Barreto, Amirhossein Sahbekar Heat shock proteins (HSP or stress proteins) are intracellular molecules that participate in physiological cell metabolism and growth, although they are known to be involved in many stress conditions. Statins inhibit the action of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA), which is important in the synthesis of cholesterol and essential isoprenoid intermediates, thereby lowering circulating low-density lipoprot...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Conclusion: Our data proved that LCL-SIM antitumor activity in C26 colon carcinoma was based on cytotoxic effects on these cancer cells and suppressive actions on tumor angiogenesis and inflammation.
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
Background: Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) have been demonstrated to mitigate radiation-induced lung damage in animal models and preclinical studies. Our study aims to evaluate whether ACEIs or ARBs reduce the incidence of radiation-induced pneumonitis (RP) in lung cancer patients.Methods: Publications were searched from EMBASE, PubMed and Web of Science databases. Seven studies published from April 2000 to August 2016 met inclusion criteria and included 1412 patients in total. Only patients with grade 2 and above pneumonitis within 12 months after radiotherapy wer...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
AbstractMcArdle disease is an autosomal recessive condition caused by deficiency of thePYGM gene-encoded muscle isoform of glycogen phosphorylase. Some cases of “manifesting” heterozygotes or carriers (i.e., patients who show some McArdle-like symptoms or signs despite being carriers of only one mutatedPYGM allele) have been reported in the literature but there is controversy, with misdiagnosis being a possibility. The purpose of our study was to determine if there are actually “manifesting” heterozygotes of McArdle disease and, if existing, whether statin treatment can trigger such condition. Eight...
Source: Journal of Inherited Metabolic Disease - Category: Internal Medicine Source Type: research
Shortening of lives ‘institutionalised’ at Gosport War Memorial Hospital in 1989-2000 Related items fromOnMedica Hunt announces Medicines and Medical Devices Safety Review CQC finds safety concerns with online primary care Treatment of whistleblowers a “stain on NHS”, say MPs GPs defend practice on prescribing statins Multidisciplinary prescribing can help reduce errors
Source: OnMedica Latest News - Category: UK Health Source Type: news
In the Letter to the Editor entitled, “Reinitiation of Statin Therapy After Discontinuation: A Meta-analysis” published in the May 2018 issue of Mayo Clinic Proceedings (Mayo Clin Proc. 2018;93(5):666-668), the publication dates for 2 of the studies listed in the Figure are incorrect. The year for Vinogradova et al7 should state  2016.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Tags: Correction Source Type: research
More News: Cholesterol | Genetics | Laboratory Medicine | Statin Therapy