Association between the XPG gene rs2094258 polymorphism and risk of gastric cancer
Journal of Clinical Laboratory Analysis, EarlyView.
Conclusions: TAMs are closely associated with the growth of GC and prognosis in GC patients. GC cells may directly sustain and amplify the local pro-inflammatory response upon encountering activated macrophages and LPS via NF- κB and STAT3 signalling pathways, thereby promoting tumour progression.Cell Physiol Biochem 2018;47:1399 –1410
Condition: Advanced Gastric Cancer Interventions: Procedure: Laparoscopic gastrectomy; Procedure: Open gastrectomy Sponsor: Peking University Not yet recruiting
Authors: Liu D, Wang N, Sun Y, Guo T, Zhu X, Guo J Abstract OBJECTIVE: To analysis the expression of VEGF in gastric carcinoma cell and tumor tissue, our study determined the relationship between the expression of VEGF and tumor incidence, metastasis and prognosis in human gastric carcinoma. METHODS: Treatment of ZD6474 at dose of 30 μmol/L was performed in gastric carcinoma cell BGC823. qPCR and Western-blot were used to analysis the mRNA and protein expression of VEGF. MTT, wound healing and Transwell experiments were conducted to study the effect of VEGF on tumor incidence, metastasis and prognosis. ...
In conclusion, IL-21 used alone and in combination with 5-Fluorouracil are anti-tumor mechanisms in SGC-7901. PMID: 29921390 [PubMed - in process]
My colleagues and I thank Matsushita et al1 for their response to our article entitled “Peritoneal carcinomatosis from signet-ring cell adenocarcinoma of the appendix.”2 We agree that with signet-ring cell carcinoma, the primary tumor site is most commonly the stomach and that accurate diagnosis of a primary gastric cancer is diffi cult to make in patients without gastric symptoms. We also agree that positron emission tomography plays a less-useful diagnostic role in the detection of primary gastric cancer, especially in patients with signet-ring cell carcinoma.
We read with great interest the recent article in which Kanesaka et al1 reported a computer-aided system for identifying early gastric cancers (EGC). The diagnostic performance (accuracy of 96.3%) suggests the great potential of computer-aided diagnosis for EGC. This is especially true in countries such as China that have a high incidence of gastric cancer but a low EGC detection rate.2 Recent reports3 have estimated that about 679,100 new cases of gastric cancer were confirmed in China each year and that more than 80% of patients received their diagnoses at an advanced stage with poor prognosis.
Conclusions: These results demonstrate that this adjuvant regimen is active with an acceptable toxicity profile. A randomized phase 3 trial comparing the Intergroup 0116 chemoradiotherapy regimen with this regimen is underway.
This article describes advances in combined modality treatment of peritoneal metastases, specifically with an emphasis on peritoneal-directed therapies.
(Natural News) You may want to rethink about downing another bottle of beer. Scientists have confirmed that alcohol increases the risk of getting cancer. Research revealed that frequent alcohol drinkers are more prone to contract cancers of the oral cavity and pharynx, esophagus, larynx, breast, liver, colon or rectum, and stomach. Several studies were conducted aiming...
ConclusionThe saponins from PC exhibited signififi cant cytotoxicity against human EC9706, KB, BGC-823, and HepG-2 cells and might be benefifi cial to development of ethnic pharmaceutical plant for potential anti-tumor drugs.