Deoxycytidine kinase expression underpins response to gemcitabine in bladder cancer.

Conclusions:Gemcitabine resistance in bladder cancer cell lines was associated with decreased dCK expression, but gemcitabine-resistant xenografts were responsive to combination low-dose gemcitabine/IR. We propose that dCK activity in tumour vasculature renders it gemcitabine-sensitive, which is sufficient to invoke a tumour response and permit tumour cell kill in gemcitabine-resistant tumours.
PMID: 25224279 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - September 15, 2014 Category: Cancer & Oncology Authors: Kerr M, Scott H, Groselj B, Stratford M, Karaszi K, Sharma N, Kiltie AE Tags: Clin Cancer Res Source Type: research