Knee Osteoarthritis after Arthroscopic Partial Meniscectomy: Prevalence and Progression of Radiographic Changes after 5 to 12 Years Compared with Contralateral Knee

J Knee Surg DOI: 10.1055/s-0038-1646926The purpose of this study was to study the clinical and radiographic changes in the knee after arthroscopic partial meniscectomy (APM) at a long-term follow-up compared with the contralateral knee. We assessed 57 patients (38 males and 19 females) with pre- and postoperative weight-bearing radiography with a follow-up ranging from 5.1 to 12.1 years (mean: 8.1) to analyze prevalence and progression of knee osteoarthritis (OA) after APM. We stratified patients according to body mass index (BMI), type of lesion (degenerative vs. traumatic), and side of meniscectomy (medial, lateral, and medial plus lateral). Patients were evaluated both clinically with Knee Osteoarthritis Outcome Score (KOOS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score and radiographically with the Kellgren and Lawrence (K/L) score. Radiographic OA was defined as K/L grade 2 or worse. The prevalence of knee OA was 62.69% in the tibiofemoral compartment. The progression of knee OA was statistically significant, ranging from 17.2% preoperatively to 65.95% postoperatively (p = 0.001) in the medial compartment and from 17.64% preoperatively to 58.82% postoperatively (p = 0.0324) in the lateral compartment. The progression of knee OA in the patellofemoral compartment ranged from 5.26 to 42.10% (p = 0.001). The OA progression regarding BMI was higher into the obese group than the normal-weight group an...
Source: Journal of Knee Surgery - Category: Orthopaedics Authors: Tags: Original Article Source Type: research

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ConclusionDespite minimal group-level effects of chronic diet-induced obesity and voluntary wheel running on knee OA pathology under the current test durations, diet and exercise substantially altered the relationships among systemic and local variables associated with early-stage knee OA. These results suggest that distinct pre-OA phenotypes may exist prior to the development of disease.Graphical Abstract
Source: Journal of Sport and Health Science - Category: Sports Medicine Source Type: research
ConclusionThis study has evidenced that there is a large percentage of sub-threshold population. i.e. K-L grade 1 which is considered as border-line or doubt-full as far as OA diagnosis. Awareness of OA should be initiated at community level, which is needed for prevention of OA at early age.
Source: Journal of Clinical Orthopaedics and Trauma - Category: Orthopaedics Source Type: research
To examine whether metformin use was associated with knee cartilage volume loss over 4  years and risk of total knee replacement over 6 years in obese individuals with knee osteoarthritis.
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research
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Source: Obesity - Category: Eating Disorders & Weight Management Authors: Tags: Obesity (Silver Spring) Source Type: research
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Source: Obesity - Category: Eating Disorders & Weight Management Authors: Tags: Obesity (Silver Spring) Source Type: research
There is a need to identify reliable biomarkers that can predict knee osteoarthritis (OA) progression. We investigated a panel of adipokines and some related inflammatory factors alone and their ratios for their associative value at assessing cartilage volume loss over time and symptoms in obese (High BMI) and non-obese (Low BMI) OA subjects.
Source: Osteoarthritis and Cartilage - Category: Rheumatology Authors: Source Type: research
Publication date: Available online 7 May 2019Source: Journal of OrthopaedicsAuthor(s): Subhadra Poornima, Krishna Subramanyam, Imran Ali Khan, Sumanlatha G, Qurratulain HasanAbstractIntroductionOsteoarthritis (OA) is a multifactorial disease with genetic factors playing a crucial role, and it has been associated with a family history of obesity. G595C polymorphism in the sterol regulatory element-binding protein 2 (SREBP2) gene has demonstrated an association with knee osteoarthritis (KOA) patients. However, this polymorphism has been never explored in an Indian population. Hence, the current study aimed to examine whether...
Source: Journal of Orthopaedics - Category: Orthopaedics Source Type: research
Conditions:   Diabetes;   High Blood Pressure;   Obesity;   Hypertension;   Heart Diseases;   Stroke;   TIA;   Osteoarthritis;   Cancer Intervention:   Behavioral: Nutrition Education Sponsor:   Mayo Clinic Recruiting
Source: - Category: Research Source Type: clinical trials
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
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