Mechanism of Hyperkalemia-Induced Metabolic Acidosis

Conclusions Hyperkalemia decreases proximal tubule ammonia generation and collecting duct ammonia transport, leading to impaired ammonia excretion that causes metabolic acidosis.

Source: Journal of the American Society of Nephrology : JASN - April 30, 2018 Category: Urology & Nephrology Authors: Harris, A. N., Grimm, P. R., Lee, H.-W., Delpire, E., Fang, L., Verlander, J. W., Welling, P. A., Weiner, I. D. Tags: Basic Research Source Type: research