The Rodent Tibia Fracture Model: A Critical Review and Comparison with the Complex Regional Pain Syndrome Literature

• This review compared a rodent tibia fracture model (TFM) to the CRPS literature• The TFM generated nociceptive and inflammatory symptoms resembling early CRPS• Neuropeptide signaling and cytokine expression are up-regulated after fracture• Fracture activated spinal glia and induced changes in brain dendritic architecture• B cell production of IgM autoantibodies also contributed to post fracture pain
Source: The Journal of Pain - Category: Materials Science Authors: Tags: Critical Review Source Type: research