Use of Matrix-Assisted Laser Desorption Ionization –Time of flight Mass Spectrometry to identify MLST clade 4 Clostridium difficile isolates

Clostridium difficile is the leading cause of health care-associated infections. Previous studies suggest that C. difficile MLST clade 4 strains with higher drug resistance rates constitute the major clone spreading in China. Thus development of a rapid and accurate typing method for these strains is needed to monitor the epidemiology of this clone and to guide clinical treatment. A total of 160 non-duplicate C. difficile isolates recovered from three large teaching hospitals in Beijing were studied.

Source: Diagnostic Microbiology and Infectious Disease - April 26, 2018 Category: Microbiology Authors: Jing-Wei Cheng, Chang Liu, Timothy Kudinha, Meng Xiao, Shu-Ying Yu, Chun-Xia Yang, Ming Wei, Guo-wei Liang, Dong-Hua Shao, Fanrong Kong, Zhao-Hui Tong, Ying-Chun Xu Source Type: research