GSE98032 SiO2 Nanoparticles Modulate The Electrical Activity Of Neuroendocrine Cells Without Exerting Genomic Effects

Contributors : C Distasi ; FA Ruffinatti ; M Dionisi ; S Antoniotti ; A Gilardino ; G Croci ; G Alberto ; E Castrofiorio ; D Incarnato ; E Morandi ; G Martra ; S Oliviero ; L Munaron ; D LovisoloSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDifferent electrophysiological approaches are combined with a genomic screening in order to analyze, in GT1-7 neuroendocrine cells, the impact of SiO2 nanoparticles (NPs; 503nm in diameter) on electrical activity and gene expression. It is found that 20 µg mL-1 NPs induce depolarization of the membrane potential, with a modulation of the firing of action potentials. Recordings of electrical activity with Multielectrode Arrays provide further evidence that the NPs evoke a temporary increase in firing frequency, without affecting the functional beha viour on a longer time scale (hours). Finally, NPs incubation up to 24 h does not induce any change in gene expression
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research