1259 Effect of selective Gq/11-inhibition on malignant melanoma

G-protein-coupled receptors (GPCRs) comprise a large family of cell-surface receptors that transduce signals through interaction with heterotrimeric G-protein subunits (G α, Gβ, and Gy). The aberrant expression, overexpression or signal reprogramming of GPCRs and G-proteins have been linked to cancer initiation, tumor cell growth, metastasis and angiogenesis. Frequent somatic mutations of Gnaq and Gna11 were found in uveal melanomas of humans thereby identifying th ese G-proteins as potential oncogenes in human neoplasia.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Pigmentation and Melanoma Source Type: research