[Oligo- and polysacharides, proteoglycans].

[Oligo- and polysacharides, proteoglycans]. Orv Hetil. 2018 Apr;159(16):620-627 Authors: Jakab L Abstract After clearing up the confusion in the previously used nomenclature, the paper discusses the family of small-leucin-rich glycoproteins. After mentioning the family and its role in the organisation of the ground substance and in the regulation of inflammation, one unique molecule of proteoglycans is presented. This molecule is the inter-α-trypsin inhibitor. It has turned out that this peculiar molecule originally contains glycosaminoglycan beside the neutral carbohydrates. After summarizing the numerous connections of the proteoglycan molecule, the "self-sacrificing" nature of the molecule is presented. It is noted that the functions of the ovaries are also controlled by this molecule. The unique structure and fundamental function of the CD44 is also analysed. The CD44 is a transmembrane proteoglycan receptor with diverse functions and actions. The organisation has intramolecular, transmembrane sections, a stalk and one globular part and contains glycosaminoglycan and oligosacharids, too. The construction contains sialic acid residues at end positions of the molecular chains, which hinder it from joining other sialic acid structures in terminal positions. Therefore, this molecule has to be separated to open up a way for the sequencing neutral molecule (e.g., hyaluronan) to be attached. CD44 is the most important, but not the only...
Source: Orvosi Hetilap - Category: General Medicine Authors: Tags: Orv Hetil Source Type: research