GDF15 promotes the proliferation of cervical cancer cells by phosphorylating AKT1 and Erk1/2 through the receptor ErbB2.
CONCLUSIONS: Our data demonstrated that GDF15 promoted the proliferation of cervical cancer cells via the up-regulation of CyclinD1 and CyclinE1 and the down-regulation of p21 through both the PI3K/AKT and MAPK/ERK signaling pathways in a complex with ErbB2.
PMID: 29636108 [PubMed - in process]
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Li S, Ma YM, Zheng PS, Zhang P Tags: J Exp Clin Cancer Res Source Type: research
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