Diversity of the midstream urine microbiome in adults with chronic kidney disease
AbstractPurposeTo examine the characteristics of the midstream urine microbiome in adults with stage 3 –5 non-dialysis-dependent chronic kidney disease (CKD).MethodsPatients with non-dialysis-dependent CKD (estimated glomerular filtration rate [eGFR] 50% reads) by the generaCorynebacterium (n = 11),Staphylococcus (n = 9),Streptococcus (n = 7),Lactobacillus (n = 7),Gardnerella (n = 7),Prevotella (n = 4),Escherichia_Shigella (n = 3), andEnterobacteriaceae (n = 2); the rest lacked a dominant genus. The samples had high levels of diversity, as measured by the inverse Simpson [7.24 (95% CI 6.76, 7.81)], Chao [558.24 (95% CI 381.70, 879.35)], and Shannon indices [2.60 (95% CI 2.51, 2.69)]. Diversity measures were generally higher in participants with u rgency urinary incontinence and higher estimated glomerular filtration rate (eGFR). After controlling for demographics and diabetes status, microbiome diversity was significantly associated with estimated eGFR (P
CONCLUSIONS: Using data representing over 99% of U.S. population, we found that incidence rates of distant-stage prostate cancer significantly increased during 2010-2014 among men in certain ages, in white, and with non-Hispanic ethnicity. PMID: 29678312 [PubMed - in process]
CONCLUSION: CRC incidence increased with neighborhood disadvantage and racial disparities diminished with mounting disadvantage. Our results suggest additional dimensions to racial disparities in CRC outside of neighborhood disadvantage that warrants further research. PMID: 29678311 [PubMed - in process]
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