Paradoxical Acinetobacter associated Ventilator associated pneumonia incidences within prevention studies using respiratory tract applications of topical polymyxin: benchmarking the evidence base

Conclusions The mean AAVAP incidence within the control groups of studies of topical polymyxin is more than double the benchmark whereas these incidences within the groups of non-polymyxin studies and paradoxically, polymyxin intervention groups, are more similar to the benchmark. These incidences, which are paradoxical in the context of an apparent effect against VAP within controlled trials of topical polymyxin based interventions, force a reappraisal.
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research